Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies
Rattachement africain : es, be, cz, pl, se, fr, gb, de, no. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Exposure to benzophenone-1 (BP-1) and benzophenone-3 (BP-3), widely used as UV filters in personal care products, has been associated with adverse health effects. However, epidemiological evidence is limited and inconclusive, particularly in vulnerable populations such as teenagers. Objective To examine the relation between BP-1 and BP-3 concentrations and obesity, cardiometabolic biomarkers, and asthma/allergy outcomes in European teenagers, including possible sex-specific associations. Methods A multi-country cross-sectional study was conducted using pooled data from six aligned studies from the Human Biomonitoring for Europe Initiative (HBM4EU). Sociodemographic data, cardiometabolic biomarkers, and asthma/allergy outcomes were collected through questionnaires. Anthropometric data and BMI z-scores were calculated (n=1339). Plasma/serum cardiometabolic biomarkers and asthma/allergy outcomes were available for a subsample (n=173-594). Urinary BP-1 and BP-3 concentrations were adjusted for creatinine dilution using the traditional standardization (trad.) and the covariate-adjusted creatinine standardization (CAS) method. Generalized additive models, linear, logistic, and multinomial mixed models were applied, and sex-interaction terms were tested. Results Each natural log-unit increase in urinary BP-3 (CAS) concentrations was associated with higher odds of obesity in the whole population (OR: 1.20; 95% CI: 1.04-1.38). Sex-specific associations were also found with BP-1 (CAS) and BP-3 (CAS) concentrations, which were associated with higher odds of obesity in male teenagers (OR: 1.25; 95% CI: 1.01-1.55; OR: 1.34; 95% CI: 1.09-1.65, respectively). Linear mixed models showed consistent findings toward higher BMI z-scores. A negative association was found between BP-1 (CAS) concentration and serum adiponectin levels in females (% change per log e -unit increase: -3.73, 95% CI: -7.32- -0.10). BP-3 (CAS) concentrations were also associated with higher odds of non-food allergies in males (OR: 1.27; 95% CI: 1.00-1.63). Traditional creatinine adjustment showed similar or slightly attenuated estimates compared to the CAS method. Conclusions BP-1 and BP-3 exposure was cross-sectionally associated with higher odds of obesity in European male teenagers, highlighting the need to update regulations and keep exposure levels as low as practically achievable. Longitudinal studies are needed to confirm these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto de Investigación Biosanitaria de Granada pays non établi dans la noticeStructure de recherche
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Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública pays non établi dans la noticeStructure de recherche
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Universidad de Las Palmas de Gran Canaria pays non établi dans la noticeUniversité ou école supérieure
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Flemish Institute for Technological Research VITO Health pays non établi dans la noticeStructure de recherche
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Instituto de Salud Carlos III National Centre for Environmental Health pays non établi dans la noticeOrganisation à but non lucratif
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Centro Nacional de Sanidad Ambiental pays non établi dans la noticeStructure de recherche
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Masaryk University pays non établi dans la noticeUniversité ou école supérieure
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Nofer Institute of Occupational Medicine pays non établi dans la noticeStructure de recherche
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National Food Administration pays non établi dans la noticeOrganisme public
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Santé Publique France pays non établi dans la noticeInstitution
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Public Health Agency Department of Environmental and Occupational Health pays non établi dans la noticeInstitution
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German Environment Agency pays non établi dans la noticeOrganisme public
Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública et Universidad de Las Palmas de Gran Canaria, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.