GWAS identifies genetic loci for antibody response to SARS-CoV-2 vaccines in patients with systemic autoimmune diseases and healthy individuals
Rattachement africain : kr, us, hu. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract The efficacy of nucleic acid-based vaccines against SARS-CoV-2 varies across individuals, partly due to genetic factors influencing neutralizing antibody production. In patients with systemic autoimmune diseases (SADs), this response may be further altered by immune dysregulation. We conducted a genome-wide association study (GWAS) to identify genetic variants associated with post-vaccination anti-SARS-CoV-2 IgG antibody levels and to assess whether these associations differ between SAD patients and healthy individuals. The study included 165 participants (138 with SADs, 27 healthy controls), all of whom received nucleic-acid based vaccines. Antibody levels targeting the spike protein receptor-binding domain (RBD) and nucleocapsid were measured between one and twelve months after vaccination. GWAS results were meta-analyzed with data from a previously published GWAS of 1,076 healthy individuals. We identified a novel association near RACGAP1 (rs706785; βmeta=–0.30, Pmeta=3.85×10−□) and replicated a known association at HLA-DRB1 position 71 (βmeta=–0.23, Pmeta=1.94×10 −11 ). No significant interactions were observed between genotype and disease status. This study highlights both MHC and non-MHC genetic contributions to SARS-CoV-2 vaccine responses and suggests these effects are consistent across SAD patients and healthy individuals, supporting standard vaccination strategies for individuals with systemic autoimmune conditions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- GWAS identifies genetic loci for antibody response to SARS-CoV-2 vaccines in patients with systemic autoimmune diseases and healthy individuals
- Date Crossref
- 16/05/2025
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyung Hee University Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Arthritis and Musculoskeletal and Skin Diseases pays non établi dans la noticeStructure de recherche
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National Institute of Dental and Craniofacial Research pays non établi dans la noticeStructure de recherche
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National Institute of Diabetes and Digestive and Kidney Diseases pays non établi dans la noticeStructure de recherche
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National Institute of Environmental Health Sciences pays non établi dans la noticeStructure de recherche
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Orszagos Kornyezetegeszsegugyi Intezet pays non établi dans la noticeOrganisation à but non lucratif
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National Institute of Biomedical Imaging and Bioengineering pays non établi dans la noticeStructure de recherche
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Frederick National Laboratory for Cancer Research pays non établi dans la noticeStructure de recherche
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National Cancer Institute Division of Cancer Epidemiology and Genetics pays non établi dans la noticeOrganisme public
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Department of Health and Human Services pays non établi dans la noticeOrganisme public
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NIH Clinical Center Office of Research Support & Compliance pays non établi dans la noticeÉtablissement de santé
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Cancer Genomics Research Laboratory pays non établi dans la noticeStructure de recherche
Department of Biology — Kyung Hee University, National Institute of Arthritis and Musculoskeletal and Skin Diseases et National Institute of Dental and Craniofacial Research, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.