Antibiotic adherence and treatment completion associated with partial oral therapy versus all intravenous therapy in patients with serious Staphylococcus aureus infections
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Le résumé fourni par la source
BACKGROUND: Partial oral antibiotic therapy is a safe and effective alternative to all intravenous (IV) therapy for serious Staphylococcus aureus infections; however, antibiotic adherence and treatment completion rates associated with partial oral therapy outside of clinical trials are unknown. METHODS: This was a retrospective study of adults hospitalized with S. aureus bacteremia, endocarditis, or bone or joint infection. Co-primary outcomes of antibiotic adherence and treatment completion were compared between patients who transitioned to oral antibiotics during treatment or received all IV therapy. Factors associated with lack of treatment completion were evaluated by logistic regression. RESULTS: Of 249 patients, 148 (59%) and 101 (41%) were treated with partial oral or all IV therapy, respectively. Use of partial oral therapy was more common for bone or joint (73% of cases) than bloodstream infections (21% of cases). Antibiotic adherence was similar between the partial oral and all IV groups; 90% and 98% of patients completed the planned course, respectively (p = 0.38). By logistic regression, partial oral therapy was independently associated with lack of treatment completion (odds ratio 4.53 [95%CI 1.0-20.6]). Clinical failure occurred in 26% and 25% of patients who received partial oral and all IV therapy, respectively (p = 0.87). CONCLUSIONS: In clinical practice, a high proportion of patients treated with partial oral therapy for serious S. aureus infections completed treatment, but partial oral therapy was an independent risk factor for failure to complete treatment. These findings highlight the importance of identifying and addressing barriers to adherence when considering oral therapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antibiotic adherence and treatment completion associated with partial oral therapy versus all intravenous therapy in patients with serious Staphylococcus aureus infections
- Date Crossref
- 17/05/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Denver Health Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Colorado Denver pays non établi dans la noticeUniversité ou école supérieure
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Denver Public Health pays non établi dans la noticeOrganisme public
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National Patient Safety Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Department of Pharmacy pays non établi dans la noticeInstitution
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Department of Infection Prevention pays non établi dans la noticeInstitution
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Department of Medicine and Division of Infectious Diseases pays non établi dans la noticeInstitution
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University of Colorado School of Medicine Department of Medicine and Division of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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Department of Patient Safety and Quality pays non établi dans la noticeInstitution
Denver Health Medical Center, University of Colorado Denver et Denver Public Health, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.