Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients
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Le résumé fourni par la source
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the leading causes of chronic liver disease, affecting 30% of the global adult population and continuing to rise. Objective: We aimed to assess the effect of a two-year follow-up Mediterranean diet intervention on parameters of liver health in MASLD patients. Methods: Sixty-two people between 40 and 60 years of age, all diagnosed with MASLD, were enrolled in the two-year clinical trial, who were randomly assigned to one of three interventions following the Mediterranean diet pattern and the promotion of physical activity. After the intervention, the participants were categorized into two groups according to their progress in adhering to the Mediterranean diet (MedDiet), which was assessed at four follow-up time points, conducted at the start of this study and after 6, 12, and 24 months of intervention. A multivariate general linear model adjusted for age, sex, and intervention (diet and physical activity) was used. Bonferroni’s post hoc test identified differences between groups and sessions within the same group. Results: Participants in the highly adherent group showed significantly stronger improvement in anthropometric measures, lipid profile, and liver enzyme levels during the follow-up period, along with a reduction in the Dietary Inflammatory Index, intrahepatic fat content, the fatty liver index, and plasma cytokeratin-18 levels compared to baseline. The progress observed in several parameters at 12 months came to a standstill, likely because of the COVID-19 pandemic at that time. At 24 months, following the COVID-19 pandemic, these parameters improved as a result of better adherence to the Mediterranean diet. Conclusions: Greater adherence to the Mediterranean diet, along with increased physical activity, significantly enhances liver health markers in individuals with MASLD. These findings support the Mediterranean lifestyle as an effective non-pharmacological strategy to improve liver health and prevent liver-related complications in MASLD patients, potentially reducing the future public health burden.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients
- Date Crossref
- 14/05/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto de Salud Carlos III CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) pays non établi dans la noticeOrganisme public
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Health Research Institute of the Balearic Islands pays non établi dans la noticeStructure de recherche
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Research Institute of Health Sciences pays non établi dans la noticeStructure de recherche
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Universitat de les Illes Balears pays non établi dans la noticeUniversité ou école supérieure
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Fundació Balear d'Innovació i Tecnologia pays non établi dans la noticeOrganisation à but non lucratif
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Hospital Universitario Son Espases pays non établi dans la noticeÉtablissement de santé
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University of Balearic Islands-IUNICS Research Group on Community Nutrition & Oxidative Stress pays non établi dans la noticeUniversité ou école supérieure
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Radiodiagnosis Service pays non établi dans la noticeInstitution
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C.S. Camp Redó pays non établi dans la noticeInstitution
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University Hospital Son Espases Clinical Analysis Service pays non établi dans la noticeUniversité ou école supérieure
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) — Instituto de Salud Carlos III, Health Research Institute of the Balearic Islands et Research Institute of Health Sciences, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.