ω‐3 PUFAs Alleviate GJ‐Cx43 Uncoupling Induced by Long‐Term Isoflurane Exposure by Activating the Wnt/β‐catenin Signaling Pathway in Astrocytes

Résumé fourni par la source

Isoflurane, a widely used anesthetic, has raised concerns due to its potential neurotoxic effects, including oxidative stress and astrocytic gap junction (GJ) dysfunction. This study investigates whether ω-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can mitigate these effects by activating the Wnt/β-catenin signaling pathway. Using primary astrocytes, we found that long-term isoflurane exposure uncoupled GJ-Cx43, increased reactive oxygen species (ROS), and inhibited Wnt/β-catenin signaling. ω-3 PUFA treatment restored GJ-Cx43 coupling, reduced ROS levels, and partially reactivated the Wnt/β-catenin pathway. These findings suggest that ω-3 PUFAs protect against isoflurane-induced neurotoxicity by enhancing GJ-Cx43 coupling and reducing oxidative stress, offering a potential therapeutic strategy for perioperative neurocognitive disorders."

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