Exosomes Derived from the Serum of Mice That Received a Huoxue Yiqi Recipe Promote Angiogenesis Following Myocardial Infarction
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Le résumé fourni par la source
Proangiogenic therapy offers a promising strategy for treating and preventing heart failure and cardiac remodeling following a myocardial infarction (MI). Although exosome-based proangiogenic therapy has significant potential in regenerative medicine and MI treatment, its application remains limited by suboptimal therapeutic efficacy. Here, we present exosomes (HXYQR-Exo) derived from the serum of mice treated with the Huoxue Yiqi Recipe (HXYQR) to promote angiogenesis and repair cardiac tissue post-MI, with a systematic elucidation of the underlying mechanisms. Our findings show that HXYQR-Exo incorporates pharmaceutically active components of HXYQR, enhancing the proliferation, invasion, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) under hypoxic conditions. In vivo studies demonstrate significant improvements in cardiac function and angiogenesis. Mechanistic investigations reveal that these effects are mediated through the activation of the HIF-1α/VEGF, Focal Adhesion Kinase (FAK), and p38/Mitogen-Activated Protein Kinase-Activated Protein Kinase (MAPKAPK)/Heat Shock Protein 27 (HSP27) pathways. This study introduces an exosome-based approach for MI treatment and cardiac repair, offering an effective strategy to enhance exosome biological activities and functions via traditional Chinese medicine preconditioning.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Exosomes Derived from the Serum of Mice That Received a Huoxue Yiqi Recipe Promote Angiogenesis Following Myocardial Infarction
- Date Crossref
- 13/05/2025
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Beijing University of Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing pays non établi dans la noticeUniversité ou école supérieure
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China-Japan Friendship Hospital pays non établi dans la noticeÉtablissement de santé
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University of Science and Technology Beijing pays non établi dans la noticeUniversité ou école supérieure
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Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine pays non établi dans la noticeÉtablissement de santé
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Shenzhen University pays non établi dans la noticeUniversité ou école supérieure
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Beijing Key Laboratory for Bioengineering and Sensing Technology Research Centre for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering pays non établi dans la noticeUniversité ou école supérieure
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National Center for Integrative Medicine pays non établi dans la noticeInstitution
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School of Biomedical Engineering Marshall Laboratory of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing — Beijing University of Chinese Medicine, China-Japan Friendship Hospital et University of Science and Technology Beijing, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.