Association of Disease Severity and Cerebral Interventional Complications With Long-Term Neurodevelopmental Outcome in Neonates With Vein of Galen Malformation
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Le résumé fourni par la source
BACKGROUND: Vein of Galen malformation represents a rare but life-threatening intracranial arteriovenous shunting lesion with high mortality and poor long-term neurodevelopmental outcome in neonatal presentation. At present, predictive parameters for individual prognosis of neurological outcome are lacking. METHODS: This is a retrospective single-center analysis of the association between disease severity, determined by the percentage of retrograde volume flow in the aortic isthmus (aortic steal), occurrence of cerebral interventional complications, and neurodevelopmental outcomes (motor development, cognitive function, and language) at age two years in a consecutive cohort of neonates with vein of Galen malformation. The overall outcome was a composite of the three subcategories categorized as favorable, intermediate, and poor. RESULTS: Twelve neonates were included, of which five (42%) exhibited a favorable outcome, two (17%) an intermediate outcome with sequelae, and five (42%) a poor outcome. There was a strong correlation of aortic steal (%) with cerebral interventional complications (Spearman ρ = 0.78) and neurodevelopmental outcomes at age two years (Spearman ρ = 0.93). Occurrence of cerebral interventional complications showed a strong correlation with long-term neurodevelopmental outcomes (Spearman ρ = 0.89). CONCLUSIONS: Disease severity as indicated by aortic steal (%) is associated with cerebral interventional complications and two-year neurodevelopmental outcomes in neonates with vein of Galen malformation. Cerebral interventional complications are strongly associated with outcomes at age two years and may be a direct and mediating risk factor between aortic steal (%) and neurodevelopment outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of Disease Severity and Cerebral Interventional Complications With Long-Term Neurodevelopmental Outcome in Neonates With Vein of Galen Malformation
- Date Crossref
- 01/08/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Duisburg-Essen pays non établi dans la noticeUniversité ou école supérieure
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Sana Kliniken Duisburg pays non établi dans la noticeÉtablissement de santé
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Essen University Hospital pays non établi dans la noticeOrganisme public
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University Hospital Essen Department of Neonatology and Pediatric Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Sana Clinics Duisburg Department of Neonatology and Pediatric Intensive Care Medicine pays non établi dans la noticeÉtablissement de santé
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Clinic for Radiology and Neuroradiology pays non établi dans la noticeÉtablissement de santé
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Clinic for Neurosurgery pays non établi dans la noticeÉtablissement de santé
University of Duisburg-Essen, Sana Kliniken Duisburg et Essen University Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.