The association between statins and gait speed reserve in older adults: effects of concomitant medication
Rattachement africain : be, ch, Éthiopie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Statins are frequently prescribed to older adults, yet their effects on ageing phenotypes such as frailty or physiological reserves remain poorly understood. Gait Speed Reserve (GSR), defined as the difference between maximal and usual gait speeds, serves as an indicator of physiological reserve, reflecting the body's ability to perform beyond baseline functional levels. Polypharmacy, prevalent in this population, may contribute to inconsistent findings through interactions between statins and concomitant medications. We aimed to investigate how concomitant medications moderate the association between statin use and GSR in older adults. To this end, we conducted a cross-sectional observational cohort study using data from the Mobility Center at the University Department of Geriatric Medicine FELIX PLATTER, Basel, Switzerland (n = 5519 adults aged ≥ 60 years). Moderation regression analyses with propensity score weighting were used to evaluate the effect of concomitant medications on the association between statin use and GSR. Results showed statin use was associated with a lower GSR compared to non-use (- 1.9 cm/s [95% CI, - 3.1 to - 0.72]). However, ACE inhibitors and aspirin significantly influenced this association. The GSR difference for statin users compared to non-users increased by 3.7 cm/s (from - 2.2 to 1.5 cm/s; 95% CI, 0.0 to 7.4) with concomitant ACE inhibitor use and by 5.8 cm/s (from - 3.4 to 2.3 cm/s; 95% CI, 2.5 to 9.1) with aspirin use. We found no statistically significant association between statin use and usual gait speed, the secondary outcome. In conclusion, ACE inhibitors and aspirin interacted with statins, reversing the negative association with GSR into a positive one when co-used. Future clinical trials are needed to determine causality and further investigate the impact of concomitant medication use on statin effects in aging populations. Meanwhile, our findings underscore the importance of considering concomitant medication use when assessing the effects of statins in older adults.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The association between statins and gait speed reserve in older adults: effects of concomitant medication
- Date Crossref
- 07/05/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ghent University Hospital Department of Geriatrics pays non établi dans la noticeÉtablissement de santé
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Ghent University pays non établi dans la noticeUniversité ou école supérieure
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HOGENT University of Applied Sciences and Arts pays non établi dans la noticeUniversité ou école supérieure
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Felix Platter-Hospital pays non établi dans la noticeÉtablissement de santé
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Jimma University Jimma University, Éthiopie (code pays fourni par la source)Université ou école supérieure
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University of Basel pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Engineering and Architecture Department of Telecommunications & Information Processing pays non établi dans la noticeUniversité ou école supérieure
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University Department of Geriatric Medicine FELIX PLATTER pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmaceutical Sciences Drug Quality and Registration (DruQuaR) group pays non établi dans la noticeUniversité ou école supérieure
Department of Geriatrics — Ghent University Hospital, Ghent University et HOGENT University of Applied Sciences and Arts, avec 6 autres affiliations. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.