Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: A cross-sectional study
Rattachement africain : us, bd. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Arsenic is associated with lung disease and experimental models suggest that arsenic-induced degradation of the chloride channel CFTR (cystic fibrosis transmembrane conductance regulator) is a mechanism of arsenic toxicity. We examined associations between arsenic exposure, sweat chloride concentration (measure of CFTR function), and pulmonary function among 269 adults in Bangladesh. Participants with sweat chloride ≥ 60 mmol/L had higher arsenic exposures than those with sweat chloride < 60 mmol/L (water: median 77.5 µg/L versus 34.0 µg/L, p = 0.025; toenails: median 4.8 µg/g versus 3.7 µg/g, p = 0.024). In linear regression models, a one-unit µg/g increment in toenail arsenic was associated with a 0.59 mmol/L higher sweat chloride concentration, p < 0.001. Among the entire study population, after adjusting for covariates including age, sex, smoking, education, and height, toenail arsenic concentration was associated with increased odds of airway obstruction (OR: 1.97, 95%: 1.06, 3.67, p = 0.03); however, sweat chloride concentration did not mediate this association. Our findings suggest that sweat chloride concentration may serve as novel biomarker for arsenic exposure, warranting further investigation in diverse populations, and that arsenic likely acts on the lung through mechanisms other than inducing CFTR dysfunction. Alternative mechanisms by which environmental arsenic exposure may lead to obstructive lung disease, such as arsenic-induced direct lung injury and/or increase lung proteinase activity, require additional exploration in future work.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: A cross-sectional study
- Date Crossref
- 07/05/2025
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital Division of Pulmonary and Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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University of Pittsburgh Medical Center Department of Medicine pays non établi dans la noticeÉtablissement de santé
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University of Connecticut Department of Molecular and Cell Biology pays non établi dans la noticeUniversité ou école supérieure
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Maine Medical Center Pediatric Endocrinology and Diabetes pays non établi dans la noticeÉtablissement de santé
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MaineHealth pays non établi dans la noticeÉtablissement de santé
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Boston Children's Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Dhaka Community Hospital Trust pays non établi dans la noticeÉtablissement de santé
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Bangladesh Medical University pays non établi dans la noticeUniversité ou école supérieure
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New Balance (United States) pays non établi dans la noticeEntreprise
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New England Institute of Art pays non établi dans la noticeUniversité ou école supérieure
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Brookline Public Schools pays non établi dans la noticeUniversité ou école supérieure
Harvard University, Division of Pulmonary and Critical Care Medicine — Massachusetts General Hospital et Department of Medicine — University of Pittsburgh Medical Center, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.