Clinical Efficacy of Ex Vivo Cross-Linking on Neovascularization of the Donor Cornea Carrier Tissue for the Boston Type I Keratoprosthesis
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Le résumé fourni par la source
Purpose: To evaluate the effect of corneal cross-linking (CXL) on corneal neovascularization (CNV) between eyes that were randomized to receive either CXL or non-CXL donor corneas as the carrier tissue for Boston keratoprosthesis surgery. Design: A retrospective masked analysis of CNV from slit lamp photographs taken at postoperative weeks 16, 24, 36, and 52. Subjects: Sixty-eight donor corneas were prospectively randomized 1:1 to receive either donor corneas that underwent ex vivo CXL or were non-CXL. The images of 47 corneas that were suitable for evaluation were included in the final analysis. Methods: The slit lamp photos were analyzed morphometrically using a standardized protocol on Photoshop CS5 (Adobe Systems Inc) and ImageJ software (National Institutes of Health). Main Outcome Measures: The 2 primary metrics used to quantify CNV were neovascular area (NA), defined as the area of corneal vessels projected onto the plane of a photograph, and invasion area (IA), defined as the fraction of corneal area in which vessels are present. Results: = 0.303). Conclusions: Although not statistically significant, this study observed a trend toward a lower CNV in CXL donor corneas compared with non-CXL donor corneas, suggesting that ex vivo CXL of donor corneas may protect against CNV of the donor cornea. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Efficacy of Ex Vivo Cross-Linking on Neovascularization of the Donor Cornea Carrier Tissue for the Boston Type I Keratoprosthesis
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Penn State Milton S. Hershey Medical Center pays non établi dans la noticeÉtablissement de santé
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Massachusetts Eye and Ear Infirmary pays non établi dans la noticeÉtablissement de santé
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University of Colorado Anschutz Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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University of Colorado Denver pays non établi dans la noticeUniversité ou école supérieure
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Boston Children's Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Penn State College of Medicine Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Department of Ophthalmology pays non établi dans la noticeInstitution
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Schepens Eye Research Institute at Massachusetts Eye & Ear Department of Ophthalmology pays non établi dans la noticeStructure de recherche
Penn State Milton S. Hershey Medical Center, Massachusetts Eye and Ear Infirmary et Department of Ophthalmology — University of Colorado Anschutz, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.