Regulation of the Cell Cycle and Induction of Apoptosis in 4T1 Breast Cancer Cells by Phenolic Compound from Sterculia quadrifida Bark

Résumé fourni par la source

Breast cancer remains a significant global health concern, necessitating the ongoing search for more effective treatment strategies. Natural phenolic compounds have gained attention for their anticancer properties among potential therapeutic agents. This study investigates the cytotoxic effects of a phenolic compound on 4T1 breast cancer cells, particularly its role in inducing cell death and disrupting the cell cycle. 4T1 cells were exposed to cisplatin (3.56 µg/mL) and a phenolic compound (5.46 µg/mL), followed by flow cytometry analysis of apoptosis and cell cycle distribution. The results demonstrated that phenolic treatment induced the highest level of cell death (10.13%), exceeding that of cisplatin (6.61%). Additionally, phenolic compounds significantly promoted apoptosis and caused cell cycle arrest, accumulating cells in the S phase. These findings suggest that phenolic compounds may serve as more potent anticancer agents than cisplatin, primarily through apoptosis induction and cell cycle regulation. Further research is needed to elucidate their molecular mechanisms and explore their potential in breast cancer therapy.

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