Lower NT-Probnp Plasma Concentrations in Pacific Peoples with Heart Failure
Rattachement africain : nz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Aims Plasma concentrations of the heart failure (HF) biomarker N-terminal B-type natriuretic peptide (NT-proBNP) vary by ethnicity. We investigated whether NT-proBNP concentrations differed in HF between Pacific peoples, Māori (the Indigenous people), and New Zealand (NZ) Europeans, in patients with HF. Methods Plasma NT-proBNP was measured in patients with HF participating in two prospective NZ based multicentre studies [PEOPLE: n = 836, 30% female, median age 71, interquartile interval (IQI) 60, 80; IMPERATIVE-HF: n = 413, 30% female, median age 66, IQI 55, 76]. Regression analyses were used to understand predictors of NT-proBNP taking into account age, sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF) and presence of atrial fibrillation (AF). Results Median NT-proBNP concentrations were significantly lower in both Pacific (930 pg/mL; P < 0.001, IQI 409–1,473; n = 127) and Māori (1,387 pg/mL, IQI 685–2,393; P < 0.001; n = 221) compared with NZ Europeans (2,055 pg/mL, IQI 973–3,865; n = 901) in unadjusted comparisons. NT-proBNP was independently associated with ethnicity, age, sex, BMI, eGFR, LVEF and presence of AF. The significant differences in plasma NT-proBNP between Pacific peoples, but not Māori, and NZ Europeans remained after adjusting for these clinical and demographic factors. The effect of age on NT-proBNP concentrations differed significantly between Pacific peoples and NZ Europeans, but not between Māori and NZ European (Pinteraction = 0.0109). For each decade of life over 60 years, plasma NT-proBNP in patients with HF was on average, 67% lower in a Pacific person than that of an aged-matched NZ European. Conclusions In HF, Pacific and Māori people had significantly lower median plasma concentrations of NT-proBNP than NZ Europeans. This difference remained after adjusting for clinical and demographic factors in patients with Pacific ethnicity. Pacific peoples also had a significantly lower rate of increase of NT-proBNP with age compared with NZ Europeans and Māori.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Lower NT-Probnp Plasma Concentrations in Pacific Peoples with Heart Failure
- Date Crossref
- 28/04/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Otago Christchurch Heart Institute pays non établi dans la noticeUniversité ou école supérieure
-
University of Auckland pays non établi dans la noticeUniversité ou école supérieure
-
Wolters Kluwer Health pays non établi dans la noticeEntreprise
-
Health New Zealand Cardiology Department pays non établi dans la noticeÉtablissement de santé
-
Middlemore Hospital Cardiology Department pays non établi dans la noticeÉtablissement de santé
-
Auckland City Hospital Cardiology Department pays non établi dans la noticeÉtablissement de santé
-
Department of Medicine Faculty of Medical and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Department of Cardiology Gisborne Hospital pays non établi dans la noticeÉtablissement de santé
Christchurch Heart Institute — University of Otago, University of Auckland et Wolters Kluwer Health, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.