Association Between Vitamin D Deficiency and Tuberculosis among HIV-Negative Individuals: A Systematic Review & Meta-Analysis

Le résumé fourni par la source

Background and Objective Tuberculosis is an infectious disease mainly caused by Mycobacterium tuberculosis (MTB). It is associated with several factors, with vitamin D deficiency being a focus of current research. This systematic review aims to compare plasma vitamin D levels between TB cases and controls and examine the association between vitamin D deficiency and TB risk in HIV-negative participants through meta-analysis. Methods This study, registered with PROSPERO (CRD42024518012) and conducted per PRISMA guidelines, analyzed the association between vitamin D deficiency and tuberculosis. Searches were conducted in PubMed/Medline, Scopus, ScienceDirect, and Web of Science for studies up to March 8, 2024. Two independent reviewers screened articles, extracted data, and assessed bias. A random-effects model and R software were used for statistical analyses, with significance set at P < 0.05. Results We identified 2168 articles, and only 9 articles meeting the inclusion criteria were retained for our systematic review and meta-analysis. Sample sizes ranged from 33 to 520 participants. We found a mean difference of -6.58 ng/ml in 25(OH)D levels, indicating consistently lower levels in TB patients compared to controls (p<0.0001) and an increased risk of TB associated with VDD with a pooled OR of 2.11 (95% CI: 1.50 to 2.98), p=0.09. Conclusion This study highlights lower 25(OH)D levels in TB patients and the association between vitamin D deficiency and increased TB risk, emphasizing the need for further research, standardized clinical trials, and preventive supplementation protocols. PROSPERO Registration Number CRD42024518012

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.