Prevalence, risk characteristics, and prediction of low-dose edoxaban treatment in hospitalized patients: a multicenter, observational cohort study
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Le résumé fourni par la source
Background Treatment with a low-dose non-vitamin K antagonist oral anticoagulant (NOAC) is common among hospitalized patients, and a model to predict the need for such treatment would support individualized interventions. This study evaluated the prevalence of low-dose edoxaban treatment and developed and evaluated a model to predict low-dose administration of edoxaban among hospitalized patients. Methods This study included 1208 inpatients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) who were treated with edoxaban. Univariate and multivariate analyses identified variables significantly associated with low-dose edoxaban therapy. Least absolute shrinkage and selection operator (LASSO) regression was used for data dimension reduction and selection of the best variables. A nomogram was built based on the predictive variables for easy visualization. Model performance was evaluated, and the model was further validated internally with 1000 bootstrap resamples. Results The prevalence of low-dosing edoxaban treatment was 65.98% (797/1208). The predictors of edoxaban included in the final nomogram were age, weight, surgery or operation, anticoagulation indication, the use of antiarrhythmic drugs, anemia, and bleeding history. The model showed good discrimination with an area under the curve value of 0.792. The Hosmer‒Lemeshow test showed that the model had satisfactory goodness of fit (χ2 = 10.757, P = 0.2158). The calibration curve showed good agreement between predicted and actual probabilities. Conclusion The developed predictive model for low-dose edoxaban use among hospitalized patients was built using seven readily available variables and showed good performance. This study provides an empirical basis for early detection and intervention using a low-dose NOAC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence, risk characteristics, and prediction of low-dose edoxaban treatment in hospitalized patients: a multicenter, observational cohort study
- Date Crossref
- 28/04/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Henan Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Fujian Medical University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Fujian Medical University pays non établi dans la noticeÉtablissement de santé
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Ningde Normal University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Zhengzhou Central Hospital pays non établi dans la noticeÉtablissement de santé
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Capital Medical University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Beijing Anzhen Hospital pays non établi dans la noticeÉtablissement de santé
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Xinxiang Central Hospital pays non établi dans la noticeÉtablissement de santé
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School of Clinical Medicine Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Pharmacy pays non établi dans la noticeÉtablissement de santé
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Central's Hospital of Xinxiang Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
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The First People's Hospital of Xinxiang Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
Henan Provincial People's Hospital, Department of Pharmacy — Fujian Medical University et First Affiliated Hospital of Fujian Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.