Genetic and Pathogenic Characteristic of High Pathogenic Korean NADC34‐Like Porcine Reproductive and Respiratory Syndrome Virus

Le résumé fourni par la source

A novel NADC34‐like strain of porcine reproductive and respiratory syndrome virus (PRRSV), named SNUVP231106, was isolated from a farm where pigs experienced respiratory symptoms and abortions. In this study, a SNUVP231106 strain was fully sequenced and evaluated for its pathogenicity. The genomic sequence of SNUVP231106 was NADC34‐like PRRSV which was classified as sublineage 1.5 with 100 amino acid (aa) continuous deletions in nsp2. The Korean NADC34‐like PRRSV strain SNUVP231106 is a restriction fragment polymorphism pattern of 1‐6‐4 according to the genetic analysis of the open reading frame (ORF) 5 gene. Recombination analysis revealed that the Korean NADC34‐like PRRSV strain SNUVP231106 is a recombinant strain, with IA/2014/NADC34 as the major parent and both RespPRRS‐MLV and NADC30 as minor parents. Animal studies demonstrated that infection with the NADC34‐like PRRSV strain SNUVP231106 resulted in 100% morbidity and 37.5% mortality, accompanied by high viremia, elevated fever, and significant weight loss. Pathological findings included interstitial pneumonia, thymus atrophy, and perivascular cuffing in the brain. These experimental results confirm that the NADC34‐like PRRSV strain SNUVP231106 exhibits high pathogenicity in piglets.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.