Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia
Rattachement africain : Éthiopie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Accurate hematological reference intervals are critical for proper disease diagnosis and patient management. However, many Ethiopian laboratories rely on reference intervals derived from Western populations, which may not reflect the genetic, environmental, and lifestyle factors of the local population. This study aimed to establish locally derived hematological reference intervals for adults in Debre Berhan town, North East Ethiopia. A community-based cross-sectional study was conducted in Debre Berhan town Northeast Ethiopia, from May to July 2024. Two hundred forty (120 male, 120 female) apparently healthy adults were recruited using convenient sampling. Sociodemographic data were collected via Interviewer-administered pre-tested questionnaire through KoBoToolbox. Aseptically collected venous blood samples were analyzed for hematological parameters using a Mindray 5150 analyzer. Data were analyzed using Stata version 17; the 2.5th and 97.5th percentiles were used to determine RIs, and the Mann-Whitney U test was used to assess gender-based differences, with statistical significance set at p < 0.05. The established 95% hematological reference intervals (2.5th–97.5th percentile) were: WBC (3.2–9.5 × 10 9 /L), neutrophils (1.1–6.4 × 10 9 /L), lymphocytes (1.2–3.3 × 10 9 /L), monocytes (0.2–0.7 × 10 9 /L), eosinophils (0.01–0.4 × 10^9/L), RBC (4.04–6.08 × 10 12 /L), Hgb (12.3–18.8 g/dL), Hct (37.0–54.0%), MCV (81.6–99.8 fL), MCH (27.6–34.4 pg), MCHC (32.8–35.4 g/L), RDW-CV (11.8–16.2%), and platelet (136.0-407 × 10 9 /L). Males showed significantly higher median values for monocyte and eosinophil counts, RBC, Hgb, Hct, MCH, and MCHC compared to females. Conversely, females exhibited significantly higher median platelet counts than males ( p < 0.05). The reference intervals reported in this study strongly advocate for the implementation of population-specific reference intervals, ensuring accurate diagnoses and enhanced patient safety. The observed gender-based differences in hematological parameters also underscore the importance of employing gender-specific reference intervals to improve clinical decision-making.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia
- Date Crossref
- 23/04/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Debre Berhan University Department of Medical Laboratory Sciences Debre Berhan University, Éthiopie (code pays fourni par la source)Université ou école supérieure
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University of Gondar University of Gondar, Éthiopie (code pays fourni par la source)Université ou école supérieure
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Wollo University Éthiopie (code pays fourni par la source)Université ou école supérieure
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Addis Ababa University Addis Ababa University, Éthiopie (code pays fourni par la source)Université ou école supérieure
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College of Medicine and Health Sciences Department of Medical Laboratory Science Debre Berhan University, Éthiopie (pays nommé en fin d’affiliation)Université ou école supérieure
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School of Biomedical and Laboratory Sciences Department of Hematology and Immunohematology University of Gondar, Éthiopie (pays nommé en fin d’affiliation)Université ou école supérieure
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College of Health Sciences Department of Medical Laboratory Sciences Addis Ababa University, Éthiopie (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Medical Laboratory Sciences — Debre Berhan University (Debre Berhan University, Éthiopie), University of Gondar (University of Gondar, Éthiopie) et Wollo University (Éthiopie), avec 4 autres affiliations. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.