Application of cardiac magnetic resonance feature tracking (CMR-FT) for quantitative assessment of left atrial function in nonobstructive hypertrophic cardiomyopathy

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Background: Magnetic resonance imaging (MRI) is used to measure the diameter and volume of the left atrium in patients with nonobstructive hypertrophic cardiomyopathy (NOHCM). However, these morphological data cannot explain the complexity of left atrial (LA) function. The study aimed to evaluate LA function by applying cardiac magnetic resonance feature tracking (CMR-FT) for LA strain analysis in patients with NOHCM, and to examine the impact of NOHCM on LA and left ventricular (LV) structure and function. Methods: test, were used to compare the differences in quantitative parameters between the two groups. The diagnostic efficacy of LA parameters was assessed using receiver operating characteristic (ROC) curves. Pearson or Spearman correlation coefficients were applied to analyze the relationships between the structural and functional parameters of the left atrium and ventricle. Results: , P<0.001] values were significantly lower compared to the HC group (P<0.05). The combined index test showed the highest diagnostic efficacy for LA impairment in NOHCM patients with normal LAVI (AUC =0.838). Strong correlations were observed between LATEF and εs (r=0.811, P<0.01), LAPEF and εe (r=0.758, P<0.01), and LAAEF and εa (r=0.827, P<0.01) across all cases. Conclusions: The measurement of LA strain by CMR-FT is a feasible and reliable method for assessing LA function. Myocardial reservoir and conduit function of the LA decline prior to LA enlargement, and strain parameters enable early detection of LA dysfunction. The combination of LA strain parameters with ejection fraction provides added value in diagnosing LA dysfunction. LA ejection fraction (LAEF) across all phases of the LA cycle shows a strong correlation with strain parameters.

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