Immunohistochemical expression of PD-L1 in colorectal carcinoma among black patients and the clinicopathological correlates: a cross-sectional study
Rattachement africain : Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Colorectal cancer (CRC) incidence is rising in Nigeria, with majority of patients presenting with advanced disease. Despite promising results of PD-L1 antibody therapy in clinical trials, efficacy data exclusively derives from Caucasian populations, leaving a critical knowledge gap for African populations. This study investigated PD-L1 expression in CRC among blacks, correlating it with clinicopathologic parameters. METHODS: The immunohistochemical expression of PD-L1 was evaluated in 96 cases of CRC diagnosed between February 2022 and January 2024, using formalin-fixed paraffin-embedded (FFPE) tissue blocks. Statistical analysis was performed using SPSS version 25. The relationships between the PD-L1 expression and the clinicopathological parameters of CRC patients were determined using the chi-square test and Spearman's rank correlation. p < 0.05 was considered to be statistically significant. RESULTS: CRC showed a male: female ratio of 1:1.8, most occurred in the seventh decade and 54.17% were right-sided. Adenocarcinoma NOS accounted for 72.5%. The majority (n = 55, 57.3%) of the patients were diagnosed at an advanced stage. PD-L1 expression was observed in 86.46% of cases, significantly correlating with tumour Size (r = 0.263, p = 0.010*), histologic Grade (r = 0.446, p = 0.000*) and tumour Stage (r = 0.367, p = 0.000*). CONCLUSION: This study highlighted the high frequency of PD-L1 expression in CRC among black patients, with significant associations to clinicopathologic parameters. The findings suggest the potential benefit of PD-1/PD-L1 targeted therapies and emphasize the need for enhanced early detection and screening in Nigeria.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immunohistochemical expression of PD-L1 in colorectal carcinoma among black patients and the clinicopathological correlates: a cross-sectional study
- Date Crossref
- 20/04/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nnamdi Azikiwe University Department of Histopathology Nnewi, Nigéria (code pays fourni par la source)Université ou école supérieure
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Nnamdi Azikiwe University Teaching Hospital Nigéria (code pays fourni par la source)Établissement de santé
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Chukwuemeka Odumegwu Ojukwu University Department of Surgery Awka, Nigéria (code pays fourni par la source)Université ou école supérieure
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Faculty of Basic Clinical Sciences Department of Anatomic Pathology and Forensic Medicine Awka, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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College of Nursing Department of Nursing Nnewi, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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Faculty of Medicine Department of Surgery Nnewi Campus, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Histopathology — Nnamdi Azikiwe University (Nnewi, Nigéria), Nnamdi Azikiwe University Teaching Hospital (Nigéria) et Department of Surgery — Chukwuemeka Odumegwu Ojukwu University (Awka, Nigéria), avec 3 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.