Role of InterLeukin-6 monitoring during weaning from volume-controlled ventilation in patients with COVID-19 acute respiratory distress syndrome
Rattachement africain : fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ObjectiveThe aim of this study was to assess the ability of plasma InterLeukin-6 (IL-6) monitoring to predict the failure to switch from volume-controlled ventilation to spontaneous ventilation (SV) in patients with COVID-19-related acute respiratory distress syndrome (ARDS).MethodsWe conducted an observational, single-center and prospective cohort study in the medico-surgical intensive care unit of Avignon Hospital Center. Participants were adult patients requiring invasive mechanical ventilation for COVID-19-related ARDS between August 2021 and August 2022, who were eligible for switching from volume-controlled ventilation to SV.ResultsAmong the 35 patients included in the study, 13 (37%) successfully switched from controlled ventilation to SV, while 22 failed (63%). In the failure group, mean plasma IL-6 levels were higher than in the successful group from hour 0 (defined as the moment of the switch to SV mode) to 48 h. However, differences between groups became significant from 24 h (362.8 vs. 33.6 pg/mL, P = 0.002). Interestingly, between-group differences in plasma C-reactive protein (CRP) levels were only significant between groups from 48 h (129.3 vs. 52.2 mg/L, P = 0.017). Finally, IL-6 and CRP had a similar ability to predict the failure to switch to SV mode: area under the receiving operative curves 0.763 [95%CI: 0.633-0.893] and 0.753 [95%CI: 0.595-0.911], respectively (P = 0.87).ConclusionsIL-6 and CRP are inflammatory biomarkers predictive of failure to switch to SV mode in COVID-19 ARDS patients. Our results showed that IL-6 can detect failure earlier than CRP. However, larger multicenter studies are needed to confirm our results, particularly in other ARDS models.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Role of InterLeukin-6 monitoring during weaning from volume-controlled ventilation in patients with COVID-19 acute respiratory distress syndrome
- Date Crossref
- 01/04/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Université d'Avignon et des Pays de Vaucluse pays non établi dans la noticeUniversité ou école supérieure
-
Centre National de la Recherche Scientifique pays non établi dans la noticeOrganisme public
-
Inserm pays non établi dans la noticeOrganisme public
-
Université de Montpellier pays non établi dans la noticeUniversité ou école supérieure
-
Henri Duffaut Avignon General Hospital Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
-
Institut de Formation en Ostéopathie du Grand Avignon (IFO-GA) SCientific and Osteopathic Research Department pays non établi dans la noticeStructure de recherche
-
Montpellier University National Centre for Scientific Research (CNRS) pays non établi dans la noticeUniversité ou école supérieure
Université d'Avignon et des Pays de Vaucluse, Centre National de la Recherche Scientifique et Inserm, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.