PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Emerging viral infections during pregnancy: understanding the risks to maternal and fetal health

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In brief: Emerging viral infections pose a significant risk to pregnant women and their offspring. This review summarizes what is known about maternal and fetal outcomes following infection with emerging viruses and discusses how we can prepare for the next outbreak. Abstract: Viral infections during pregnancy pose significant risks to both maternal and fetal health. While several viruses are well known to cause adverse pregnancy outcomes, often little is known about emerging viruses. This review summarizes the known maternal and fetal consequences of infection during pregnancy with novel and re-emerging viruses. Focus is placed on viruses such as Zika and SARS-CoV-2, among others, discussing the mechanisms by which these viruses may disrupt fetal development at the maternal-fetal interface. The review also addresses the challenges that need to be overcome, such as the need for ongoing disease surveillance, prioritization of pregnant women for clinical trials and the importance of pre-clinical models of placenta infection, to adequately prepare for the next virus outbreak.

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