Obesity and blunted FGF23 response associate with kidney impairment in patients with hypoparathyroidism
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Le résumé fourni par la source
PURPOSE: Chronic kidney disease (CKD) is a common complication of patients affected by chronic hypoparathyroidism managed with conventional therapies. However, no data are currently available regarding the endocrine and metabolic determinants of renal function in these patients. METHODS: This was a multicenter observational study performed in three health-care centres. Patients with hypoparathyroidism were consecutively enrolled during follow-up visits in 2022-2023. These exclusion criteria were adopted: patients managed with dialysis, proteinuria (>200 mg/24 h), use of antihypertensive drugs including thiazides, ACE-inhibitors, angiotensin-II-receptor antagonists, alpha-beta blocking-agents, aldosterone-antagonists, and insulin-treated diabetes. RESULTS: ) was found in the 21.7% of patients. Patients with CKD were older, affected by a longer-disease, more frequently obese and with higher BMI. In multivariate analyses, obesity resulted as the only significant independent risk factor associated with CKD. In addition, a significant negative correlation was found between BMI and eGFR, and ROC analyses showed a significant global-performances of BMI to predict CKD. Patients with CKD were characterized also by higher FGF23 levels. A significant negative correlation was found between FGF23 and eGFR, however, evaluating separately those with and without CKD, this correlation remained significant only in the second group. CONCLUSIONS: For the first-time, obesity was demonstrated to be independently associated with CKD in patients with hypoparathyroidism, and a blunted eGFR-related response of FGF23 was shown in patients with CKD potentially worsening the renal function in the context of hypoparathyroidism.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Obesity and blunted FGF23 response associate with kidney impairment in patients with hypoparathyroidism
- Date Crossref
- 16/04/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Vita-Salute San Raffaele University pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Ospedale San Raffaele pays non établi dans la noticeÉtablissement de santé
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Ospedale Santa Chiara pays non établi dans la noticeÉtablissement de santé
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Institute of Endocrine and Metabolic Sciences pays non établi dans la noticeStructure de recherche
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Santa Chiara Hospital Internal Medicine Division pays non établi dans la noticeÉtablissement de santé
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Endocrinology Unit pays non établi dans la noticeInstitution
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Laboratory Medicine Service pays non établi dans la noticeStructure de recherche
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Unit of Nephrology and Dialysis pays non établi dans la noticeInstitution
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Medical Pharma Consultant pays non établi dans la noticeInstitution
Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele et Ospedale Santa Chiara, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.