The Spectrum and Burden of COVID-19–Associated Neurologic Disease in Australian Children 2020–2023
Rattachement africain : nz, au, gb, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: We aimed to describe the clinical spectrum and burden of COVID-19-associated neurologic disease in Australian children. METHODS: We extracted Australian national sentinel site surveillance data on COVID-19-associated neurologic disease in children hospitalized in the Paediatric Active Enhanced Disease Surveillance network, 2020-2023. Neurologic complications included encephalitis, encephalopathy, Guillain-Barre syndrome, seizures and cerebrovascular accident among others. We calculated the proportion of hospitalized pediatric COVID-19 cases associated with neurologic disease and described the spectrum of presentations including clinical features and severity. We calculated incidence rates of neurologic disease within COVID-19 variant eras among hospitalized patients. RESULTS: We identified 311 cases of SARS-CoV-2 infection with neurologic disease among 4616 hospitalized pediatric cases of COVID-19 reported through the surveillance network, representing 5.3 cases per 100 pediatric COVID-19 admissions. The most common COVID-19-associated neurologic presentations were seizures (n = 215), including febrile seizures. Nonspecific encephalopathy (n = 62), encephalitis, Guillain-Barre Syndrome, acute cerebellar syndromes, acute demyelinating encephalomyelitis and cerebrovascular accident were also reported. Almost 60% of children were ≤4 years, approximately 30% had pre-existing neurologic conditions and almost half had other medical comorbidities. COVID-19-associated neurologic complications infrequently led to death, although 25% (n = 2/8) of children with COVID-19 encephalitis died. The incidence rate of COVID-19-associated neurologic disease was lowest during the late Omicron era. CONCLUSIONS: Neurologic complications among COVID-19 hospitalized children are relatively frequent. While most neurologic complications are transient, including seizures, encephalitis remains a cause of significant morbidity. Children with pre-existing neurologic disease and other comorbidities are at higher risk.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Spectrum and Burden of COVID-19–Associated Neurologic Disease in Australian Children 2020–2023
- Date Crossref
- 10/04/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dunedin Public Hospital pays non établi dans la noticeÉtablissement de santé
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The University of Sydney pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital at Westmead Centre of Paediatric and Perinatal Infection Research pays non établi dans la noticeÉtablissement de santé
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New Zealand Institute for Public Health and Forensic Science pays non établi dans la noticeStructure de recherche
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University of Otago Department of Preventive and Social Medicine pays non établi dans la noticeUniversité ou école supérieure
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The Kids Research Institute Australia pays non établi dans la noticeOrganisation à but non lucratif
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The University of Western Australia pays non établi dans la noticeUniversité ou école supérieure
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Princess Margaret Hospital for Children pays non établi dans la noticeÉtablissement de santé
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Queen Elizabeth II Medical Centre pays non établi dans la noticeÉtablissement de santé
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Pathwest Laboratory Medicine Department of Microbiology pays non établi dans la noticeÉtablissement de santé
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Perth Children's Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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University of Oxford Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
Dunedin Public Hospital, The University of Sydney et Centre of Paediatric and Perinatal Infection Research — Children's Hospital at Westmead, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.