The Red-cell Transfusion Strategy Dilemma in Critically Ill Patients in ICU: Is Restrictive or Liberal the Answer?

Résumé fourni par la source

Background: The primary therapeutic approach for promptly increasing haemoglobin concentration is red blood cell transfusion. However, the risk associated with RBC transfusion and the overall accessibility exhibit significant variation. Objective: This meta-analysis evaluates the comparison and outcome of restrictive and liberal transfusion strategies in intensive care unit. Methods: statistics. Results: Out of 15 eligible RCTs obtained, involving 12,439 patients. The result demonstrated no significant difference of restrictive red-cell transfusion strategy over liberal red-cell transfusion strategy in reducing mortality outcomes with a pooled effect size (relative risk [RR] 0.92; 95% confidence interval [CI] 0.78 - 1.08; I2 = 0%, indicating minimal to no difference. Similarly, analyses of secondary outcomes identified no significant differences in several clinical results. Conclusion: This present meta-analysis provides evidence that restrictive red-cell transfusion strategy doesn't significantly difference in overall mortality and several secondary clinical results of critically ill patients in ICU compared to liberal red-cell transfusion strategy. Otherwise, restrictive transfusion strategy lowered RBC transfusion requirements, and was expected to be more cost-effective.

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