2025 article

Risk factors for Early (Three-Month) Postoperative Mortality in Metastatic Spine Tumor Surgery

Takaaki Uto, Satoshi Kato, Noriaki Yokogawa, Takaki Shimizu, Satoru Demura, Yuki Shiratani, Akinobu Suzuki, Koji Tamai, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Hideaki Nakajima, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Haruki Funao, Koji Uotani, Shinji Tanishima, Koichi Sairyo, Ko Hashimoto, Chizuo Iwai, Shoji Seki, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya

2Citations signalées, ce qui n’est pas une note de qualité

37Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

STUDY DESIGN: Prospective multicenter study. OBJECTIVE: To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators. SUMMARY OF BACKGROUND DATA: Metastatic spinal tumors affect patient morbidity and mortality. Although prognostic tools exist, they have limitations, particularly in emergency situations requiring rapid assessment. Nutritional biomarkers and prognostic scores may influence outcomes, but their role in predicting early postoperative mortality after spinal tumor surgery, particularly in prospective, multicenter studies, warrants investigation. MATERIALS AND METHODS: Data from 336 patients undergoing palliative surgery for metastatic spinal tumors were collected from 35 centers. The primary outcome was three-month postoperative mortality. Univariate and multivariate logistic regression analyses with bootstrapping were performed to identify predictors of early mortality, including demographics, prognostic scores [revised Tokuhashi, Tomita, modified Glasgow Prognostic Score (mGPS), and the New England Spinal Metastasis Score (NESMS)], and nutritional biomarkers. The discriminative ability of these factors was evaluated using the receiver operating characteristic curve analysis. RESULTS: The three-month postoperative mortality rate was 15.5%, with primary cancer progression accounting for 54% of the deaths. Multivariate analysis revealed that high mGPS (OR=1.989, P =0.008) and low preoperative performance status (PS) (OR=1.412, P =0.034) were significant independent predictors of early mortality, the Tomita score showed a trend toward significance (OR=1.234, P =0.050). The mGPS demonstrated a high discriminative ability, with an area under the curve of 0.716. CONCLUSION: High mGPS and low preoperative PS are significant predictors of three-month postoperative mortality in patients undergoing surgery for metastatic spinal tumors. Incorporating the mGPS, which reflects nutritional and inflammatory status, into preoperative risk stratification is crucial for optimizing surgical decision-making. LEVEL OF EVIDENCE: Level II.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Risk factors for Early (Three-Month) Postoperative Mortality in Metastatic Spine Tumor Surgery
Date Crossref: 15/04/2025
Éditeur: Ovid Technologies (Wolters Kluwer Health)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Kanazawa University pays non établi dans la notice
Université ou école supérieure
Chiba University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Osaka Metropolitan University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Kobe University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Kagoshima University pays non établi dans la notice
Université ou école supérieure
Kansai Medical University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
University of Tsukuba Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Kitasato University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Jichi Medical University Rehabilitation Center pays non établi dans la notice
Université ou école supérieure
Jichi Medical University Hospital pays non établi dans la notice
Établissement de santé
Dokkyo Medical University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure
Mie University Department of Orthopaedic Surgery pays non établi dans la notice
Université ou école supérieure

Kanazawa University, Department of Orthopaedic Surgery — Chiba University et Department of Orthopaedic Surgery — Osaka Metropolitan University, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Management of metastatic bone diseaseSarcoma Diagnosis and TreatmentInflammatory Biomarkers in Disease Prognosis

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