Effect of Naltrexone on Spinal and Supraspinal Pain Mechanisms and Functional Capacity in Women with Fibromyalgia: Exploratory Outcomes from the Randomized Placebo-Controlled FINAL Trial
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Le résumé fourni par la source
BACKGROUND: The widespread pain and muscular fatigue characteristics of fibromyalgia are believed to be mediated by central mechanisms. Low-dose naltrexone (LDN) has emerged as a new treatment option for fibromyalgia, possibly modulating central mechanisms via glial or opioid receptors. METHODS: In the randomized, placebo-controlled FINAL trial, 99 women with fibromyalgia were treated with LDN or placebo for 12 weeks. In this secondary analysis, we examined the potential effects of LDN versus placebo on changes from baseline in pain tolerance, temporal summation of pain, and conditioned pain modulation (CPM) in the complete case population (45 versus 47 participants). Measures of muscular fatigue were evaluated using the 30-s chair stand test and a shoulder abduction test. RESULTS: Of the five examined outcomes, only change in CPM showed a significant between-group difference with greater enhancement following LDN treatment (2.0 kPa; 95% confidence interval (CI) 0.4-3.7 kPa) compared with placebo. Within-group changes in CPM showed an increase of 1.2 kPa (95% CI 0.05-2.4 kPa) in the LDN group and a possible decrease of 0.8 kPa (95% CI - 1.9 to 0.4 kPa) in the placebo group. CONCLUSIONS: We found a significant between-group difference in CPM change in favor of LDN. However, this difference was partly explained by a decrease in CPM in the placebo group. Sensitivity analyses showed no association between changes in CPM and clinical pain improvement, suggesting that the group-difference in CPM is a random finding. STUDY REGISTRATION: ClinicalTrials.gov (NCT0427877; registered on 30 January 2020).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of Naltrexone on Spinal and Supraspinal Pain Mechanisms and Functional Capacity in Women with Fibromyalgia: Exploratory Outcomes from the Randomized Placebo-Controlled FINAL Trial
- Date Crossref
- 11/04/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Southern Denmark Research Unit of Rheumatology pays non établi dans la noticeUniversité ou école supérieure
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Frederiksberg Hospital pays non établi dans la noticeÉtablissement de santé
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Odense University Hospital Pain Center pays non établi dans la noticeOrganisme public
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Copenhagen University Hospital The Parker Institute pays non établi dans la noticeÉtablissement de santé
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Lillebaelt Hospital pays non établi dans la noticeÉtablissement de santé
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University of Copenhagen Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health Sciences Department of Clinical Research pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Southern Denmark Department of Anesthesia pays non établi dans la noticeUniversité ou école supérieure
Research Unit of Rheumatology — University of Southern Denmark, Frederiksberg Hospital et Pain Center — Odense University Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.