The effect of COVID-19 vaccination on change in contact and implications for transmission

Résumé fourni par la source

Monitoring human behavior as epidemic intelligence can critically complement traditional surveillance systems during epidemics. Retrospective analysis of novel behavioral data streams initiated during the COVID-19 pandemic help illustrate their utility. During the pandemic, behavior changed rapidly and was increasingly influenced by individual choice in response to changes such as newly available vaccines. Vaccines provided substantial protection against severe disease and deaths; however, their effect on behavior is understudied and it is unclear if vaccine effects against infection fully offset relaxation of social distancing behaviors. We analyzed data from a longitudinal cohort sampled from U.S. households that measured contact rates, risk mitigation and COVID-19 vaccination status between August 2020-April 2022. Contact rates universally increased across survey rounds among all sociodemographic groups, but unvaccinated individuals had persistently higher contact rates. Using a multilevel generalized linear mixed effects model, we found that individuals who newly completed a primary vaccine series had an additional increase of 1.93 (95 % CI: 0.27–3.59) contacts compared to individuals who remained unvaccinated. Using observed contact rates to estimate transmission, we found that observed increases in contact rates were not fully offset by vaccine protection against infection, but transmission was still maintained below levels without distancing and vaccination despite clusters of individuals with high contact and no vaccination. We estimated changes in contact rates following vaccination and inferred the joint effect of changes in vaccination and contacts on population-level transmission, finding that observed increases in contact rates were not fully offset by vaccine effects. Our work highlights the potential utility of ongoing longitudinal monitoring of contact patterns during epidemics. • We use longitudinal data from the U.S. to examine how person-to-person contact differed by COVID-19 vaccination status. • Unvaccinated individuals had persistently high contacts while recently vaccinated individuals had greater increases. • Increases in contact were not fully offset by vaccine protection against infection, leading to increased transmission. • Despite increases in contacts, transmission is unlikely to surpass levels observed without distancing and vaccination. • Real-time measurements of contact rates can help monitor behavior change in outbreaks and their effect on transmission.

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