Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy

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Objective This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (DoC) in response to acute pressure pain stimulation using near-infrared spectroscopy (NIRS). Methods Patients diagnosed with DoC underwent pressure stimulation while brain activity was measured using NIRS. Changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) concentrations were monitored across several regions of interest (ROIs), including the primary somatosensory cortex (PSC), primary motor cortex (PMC), dorsolateral prefrontal cortex (dPFC), somatosensory association cortex (SAC), temporal gyrus (TG), and frontopolar area (FPA). Functional connectivity was assessed during pre-stimulation, stimulation, and post-stimulation phases. Results No significant changes in HbO or HbR concentrations were observed during the stimulation vs. baseline or stimulation vs. post-stimulation comparisons, indicating minimal activation of the targeted brain regions in response to the pressure stimulus. However, functional connectivity between key regions, particularly the PSC, PMC, and dPFC, showed significant enhancement during the stimulation phase (r > 0.9, p < 0.001), suggesting greater coordination among sensory, motor, and cognitive regions. These changes in connectivity were not accompanied by significant activation in pain-related brain areas. Conclusion Although pain-induced brain activation was minimal in patients with DoC, enhanced functional connectivity during pain stimulation suggests that the brain continues to process pain information through coordinated activity between regions. The findings highlight the importance of assessing functional connectivity as a potential method for evaluating pain processing in patients with DoC.

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