Accès ouvert déclaré2025article
CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study
Sean M. Lang, Dongngan T. Truong, Andrew J. Powell, Valiantsina Kazlova, Jane W. Newburger, Jordan D. Awerbach, Edem Binka, Tamara T. Bradford, Mark Cartoski, Andrew L. Cheng, Michael P. DiLorenzo, Audrey Dionne, Adam L. Dorfman, Matthew D. Elias, Olukayode Garuba, Jennifer F. Gerardin, Keren Hasbani, Pei‐Ni Jone, Christopher Z. Lam, Nilanjana Misra, Lerraughn Morgan, Arni Nutting, Jyoti Patel, Joshua D. Robinson, Eleanor L. Schuchardt, S. Kristen Sexson Tejtel, Gautam K. Singh, Timothy C. Slesnick, Felicia Trachtenberg, Michael D. Taylor, Gail D. Pearson, Victoria L. Pemberton, Kristin M. Burns, D’Andrea Freemon, Julie Miller, Kerri Hayes, Allison Crosby‐Thompson, Ayesha Amarnath, James Ambrosoli, Cassandra Artis, Kay Rubio, Chitra Kinhikar, Amanda Marshall, PJ Mu, Devine Mbiydzenyuy, Chenwei Hu, Lozan Eyob, Beverly Slayton, Lauren DiStefano, Jami Honig, Tiffany Bowie, Rob Nero, Emily Birmingham, Robin Rowe, Melissa Joyce, Cole Gallagher, Djenawa Bowman, Mo Zhang, Alissa Mooney, Brian W. McCrindle, Andréea Dragulescu, Rae S. M. Yeung, Beth Gamulka, Jessica Bainton, Martha Rolland, Patti Walter, Simran Mahanta, Thomas Giorgio, Numaira Khan, Annette Baker, Lisa Jean Buckley, Jessica Jones, LaTina Watson, Anna Clarke, Tor-Samuel-Aleer Leek, Gwendolyn Orav, Tonia Morrison, Katherine Lupton, Therese M. Giglia, Donna Sylvester, Dana Albizem, Kristin Lanzilotta, Grace Marks, Kimberly E. McHugh, Tyler Kasmarcak, Madison Johnson, Megan M. Bickford, Linda M. Lambert, Lilly Fagatele, Andrea L. Dunn, Emma Joyce, Mark W. Russell, Tammy Doman, Elise Pickering, Marisa Almaguer, Lauryn Dugan, Kathleen Rathge, Elle Seibert, Mark Payne, Mary Stumpf, Jennifer L. Howell, Nancy Kehlenbrink, Gloria Mitscher, Matthew E. Oster, Melissa S. Burnett, Kolby Sanders-Lewis, Morgan Van Dresser, Beatrice Doe-Printemps, Brooke DiGiovanni Evans, William T. Mahle, Lazaros Kochilas, Madison Rudow, Susie Gentry, Kristie Le, Caitlen Taylor, Lara Shekerdemian, Faridis Serrano, Elias Moussi, Sandra Peña, Ricardo H. Pignatelli, Asela Liu, Kanwal M. Farooqi, Amee Shah, Brett R. Anderson, Neeka Karaminian, Katrina Golub, Chantal Sanchez, Chanel Rojas, Karen Martyrosyan, Jacqueline Szmuszkovicz, Sindhu Mohandas, Jodie K. Votava‐Smith, Shuo Wang, Pierre C. Wong, Jennifer Su, Allison Garcia, Anastasia Sarkissian, Matthew Dam, Javier Medina, Kavita Sharma, Catherine Ikemba, Maria Martinez, Parvin Mohazabnia, Wendy Rojas, Dewey Evans, Stephanie S. Handler, Joe Block, Regina Cole, Jennifer Maldonado, Shubhika Srivastava, Deepika Thacker, Carol Prospero, Varsha Zadokar, Edward J. Williams, Bridgette Hindt, Pei-Ni, Michael R. Carr, Kathleen Van’t Hof, Lauren Goodel, Colleen Sullivan, Jason Lu, Michael A. Portman, Aaron Olson, Eyal Sagiv, Sujatha Buddhe, Hidemi Kajimoto, Deepthi G. Nair, Mikayla A. Beckley, Camilla Pedroso, Kirsten Dummer, Joan Pancheri, Katheryn Crane, Sherrie Bandy, Anita Krishnan, Ashraf S. Harahsheh, Charles I. Berul, Laura Olivieri, Jordyn Britton, Mitchell Haverty, Alix Fetch, Christina Schott, Sarah Litt, Daniel Forsha, Jennifer C. Nelson, Dara Watkins, Michelle Hite, Isabel Glassmeyer, Suchitra Rao, Heather Heizer, Sonia Chavez, Arash Sabati, Ashley Herzberg, Samantha Stack, Jade Porche, Megan Warner, Susan Park, Amy J. Wagoner Johnson, Amy Ellerbe, Katherine Hildebrand, Divya Shakti, Aimee S. Parnell, Onyekachukwu Osakwe, M. David Weiland, Phenique Parker, Jeffrey A. Kertis, Charlotte V. Hobbs, Candace M. Howard, Shivraj Savadkar, Aren E. Worrell, Madelyn R. Barr, Heather Williams, David P. Gordy, Preeti Vemula, Zachary White, Jemylle Grace S. Morato, Sandra Tyler, Camden L. Hebson, Michelle Sykes, Carl Owada, Mayra Lemus Rangel, Isaura Macias, Tania Jimenez, Yamuna Sanil, Sanjeev Aggarwal, Charmaine Williams-Farr, Nancy Sullivan, Aiman Almasnaah, Vishnu Undyala, Brian Hannah, Mary Sue McCall, Emily Ward, Louis Keith, Sagar Jani, Jacob Strelow, Rachel Downey, Ken Shaffer, Chesney Castleberry, Lisa Pomeroy, Rachel Amsellem, Elizabeth Mitchell, Olga Shamailova, Arlett Zelaya, Marla Johnston, Juan Carlos Muniz, Moya Chang, Ryan Shea, Miriam Davis, Maryanne Chrisant, Danielle Katz, Norma Barton, Doris Alaby, Paulette Smith, Bukky Oni, Raquel Conceição Ferreira, Patrick McGeoghegan, Joshua Germann, Andrew S. Mackie, Jogarao Gobburu, Sally Hunsberger, Patrick S. McQuillen, Michael C. Spaeder, Dianne L. Atkins, Craig S. Broberg, David J. Driscoll, F.J. Evans, Liza‐Marie Johnson, Thomas J. Knight, Paul H. Lipkin, J. Philip Saul
5Citations signalées
28Institutions associées
2Pays d’affiliation
Résumé fourni par la source
BACKGROUND: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of patients with Multisystem Inflammatory Syndrome in Children. METHODS: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement. RESULTS: A total of 263 CMRs from 255 patients with Multisystem Inflammatory Syndrome in Children were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR. CONCLUSIONS: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed patients with Multisystem Inflammatory Syndrome in Children, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05287412.
Sujets associés
Kawasaki Disease and Coronary ComplicationsCOVID-19 Clinical Research StudiesViral Infections and Immunology Research