Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study

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BACKGROUND: The biological mechanisms linking early life phthalate exposure with adverse behaviors and cardiometabolic conditions also impact sleep health, but whether early life exposure impacts adolescent sleep is unknown. OBJECTIVES: We evaluated whether gestational and childhood urinary phthalate metabolite mixtures were associated with sleep characteristics during adolescence. We also examined periods of heightened susceptibility to individual phthalates. METHODS: . Using multiple informant models, we examined whether associations between individual phthalate metabolites and sleep characteristics varied by timing of exposure. RESULTS: ); monoethyl phthalate (MEP) and monocarboxyoctyl phthalate (MCOP) contributed most to this association. We found that higher DEHP metabolite concentrations during pregnancy were more strongly related to higher sleep fragmentation than childhood concentrations. In contrast, higher MEP and MnBP concentrations during childhood, but not pregnancy, were consistently associated with shorter sleep duration. DISCUSSION: Phthalate metabolite concentrations during pregnancy and childhood were associated with poorer adolescent sleep health. https://doi.org/10.1289/EHP15221.

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