Spontaneous Resolution of Ventricular Pre-Excitation During Childhood: A Retrospective Study
Rattachement africain : it, ch. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: Ventricular pre-excitation (VP) increases the risk of sudden cardiac death among children. While transcatheter ablation could potentially be therapeutic, it is not without risk, especially in smaller children. Accessory pathways (APs) may spontaneously lose anterograde conduction properties over time, making invasive treatment unnecessary. We aim to investigate the probability of spontaneous loss of VP during childhood, as well as the potential factors that may be associated with VP resolution. Methods: We conducted a retrospective study of patients with VP diagnosed before 12 years of age and referred to two Northern Italian tertiary care hospitals between 1993 and 2021. Patients with complex congenital heart disease were excluded. Our primary objective was to determine the likelihood of spontaneous resolution of VP. Results: Overall, 153 patients were included, with a median age at first diagnosis of 4.9 years (25th–75th percentile: 75 days–8.4 years) and a median follow-up of 4.9 years (25th–75th percentile: 1.8–8 years). Through left truncated Kaplan–Meier analysis, we estimated that anterograde conduction would persist in 53% and 33.8% of patients at the age of 1 and 16 years, respectively. Our findings revealed that the absence of symptoms and intermittent VP were associated with a higher likelihood of VP resolution. It is noteworthy that no major arrhythmic events were reported. Conclusions: Our study strongly supports the implementation of a conservative strategy in younger children with VP. Our findings indicate that a significant proportion of pediatric patients may experience spontaneous resolution of VP in the early years of their lives, making any invasive treatment unnecessary.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Spontaneous Resolution of Ventricular Pre-Excitation During Childhood: A Retrospective Study
- Date Crossref
- 29/03/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Policlinico San Matteo Fondazione pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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University of Pavia Department of Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ente Ospedaliero Cantonale pays non établi dans la noticeInstitution
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Istituto Cardiocentro Ticino pays non établi dans la noticeÉtablissement de santé
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Ospedale dei Bambini Vittore Buzzi pays non établi dans la noticeÉtablissement de santé
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Fondazione IRCCS Policlinico S. Matteo Division of Cardiology pays non établi dans la noticeÉtablissement de santé
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Cardiocentro Ticino Institute pays non établi dans la noticeStructure de recherche
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Independent Researcher pays non établi dans la noticeInstitution
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Buzzi Children’s Hospital Milano Paediatric Department pays non établi dans la noticeÉtablissement de santé
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Fondazione IRCCS Policlinico San Matteo Paediatric Cardiology Department pays non établi dans la noticeÉtablissement de santé
Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico et Department of Molecular Medicine — University of Pavia, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.