Evolution of reference intervals for renal-hepatic biomarkers and micronutrients in normal pregnancy during Covid-19 pandemic (2021–2022) in some hospitals of Kinshasa, Democratic Republic of the Congo

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Background: The aim of this study was to establish the reference intervals of renal, hepatic and micronutrient biomarkers in the course of normal pregnancy. Methods: This was a descriptive, cross-sectional, exploratory study of the occurrence of biochemical changes in reference intervals during the course of normal pregnancy between June 15, 2021 and March 30, 2022. A total of 473 pregnant women were recruited from 16 hospitals in Kinshasa. Reference intervals at 2.5 and 97.5 percentiles were established according to the recommendations of the International Federation of Clinical Chemistry. The statistical significance was set at p < 0.05. Ethical consideration was obtained from the Comité National d'Ethique en Santé and received approval under number 362/CNES/BN/PMMF/2022. Results: Mean age was 29 ± 6 years. Reference intervals (RIs) for urea, creatinine, uric acid albumin, phosphorus, calcium and magnesium; alkaline phosphatase, GGT, ALAT and ASAT were 5.4-24.7 mg/dL; 0.39-1.11 mg/dL; 2-6.4 mg/dL; 40.9-53.05 mg/dL; 2. 2-5.9 mg/dL; 6.8-11.6 mg/dL; and 1.3-3.6 mg/dL; 39-246 IU/L; 3-43IU/L; 3.78-26.19 IU/L; 7.8-35.3 IU/L. Conclusion: The established reference intervals (RIs) will be used to manage pregnancies of pregnant women in Kinshasa.

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