Anti-obesity effect of isoliquiritigenin in the 3T3-L1 cell line and a high-fat diet-induced obesity mice model

Le résumé fourni par la source

Excessive fat can lead to obesity and health risks. Increasing thermogenesis and lipolysis are effective obesity treatments. Isoliquiritigenin (ISL), found in licorice, has antioxidant, anti-inflammatory, antiviral, and anticancer properties. However, its anti-obesity effects are poorly understood. Mice treated with 50 mg/kg/d ISL for 8 weeks showed significantly lower adipose tissue weight and smaller adipocytes, indicating reduced lipid accumulation. ISL increased UCP1, HSL, and ATGL expression and electron transport chain protein levels in adipose tissue, suggesting enhanced thermogenesis and lipolysis. ISL also reduced HFD-induced adipose tissue inflammation. Additionally, ISL inhibited preadipocyte differentiation in 3T3-L1 cells by suppressing ERK/P38-MAPK signaling. These findings highlight ISL's potential as a nutraceutical agent against obesity. • ISL reduced mouse adipose weight and adipocyte size, indicating less fat accumulation. • ISL upregulated thermogenesis - and lipolysis - related proteins for weight - loss metabolism. • ISL alleviated HFD - induced adipose tissue inflammation, potentially improving metabolic health. • ISL showed anti - obesity nutraceutical potential by modulating ERK/P38 - MAPK pathway.

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