Author Correction: Spatially resolved multiomics of human cardiac niches

Résumé fourni par la source

In the drug2cell analysis of the initially published article, there was an error in filtering drug and target interactions. The activity (pChEMBL) threshold for these interactions was specifically set for each family of target molecules in accordance with the Illuminating the Druggable Genome (IDG) project. In the original manuscript, there was a discrepancy with the values from the IDG project 1 . We have now updated the threshold values (“Kinases”: revised from ≤1 μM to ≤30 nM; “GPCRs”: unchanged; “Nuclear hormone receptors”: unchanged; “Ion channels”: unchanged; “others”: revised from ≤30 nM to ≤1 μM) in both the analysis reported here and the drug2cell package ( https://github.com/Teichlab/drug2cell , version 0.1.2). The main Fig. 4b, Supplementary Table 9 and the relevant section in Methods (“Drug2cell”) have been revised accordingly. In Fig. 4b, two drugs, irbesartan and zopiclone, have been removed from the original figure due to changes in their target molecules. The main text is unaffected and therefore unchanged.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.