Accès ouvert déclaré
2025
article
Inhaled Sedation in Acute Respiratory Distress Syndrome
Matthieu Jabaudon, Jean‐Pierre Quenot, Julio Badié, Jules Audard, Samir Jaber, Benjamin Rieu, Caroline Varillon, Antoine Monsel, François Thouy, Julien Lorber, Joël Cousson, Stéphanie Bulyez, Jérémy Bourenne, G. Sboui, Claire Lhommet, Virginie Lemiale, Bélaïd Bouhemad, C. Brault, Sigismond Lasocki, François Legay, Thomas Lebouvier, Arthur Durand, Julien Pottecher, Alexandre Conia, Delphine Brégeaud, Lionel Velly, Arnaud W. Thille, Fabien Lambiotte, Erwan L’Her, Mehran Monchi, Antoine Roquilly, Aziz Berrouba, Franck Verdonk, Russell Chabanne, Thomas Godet, Marc Garnier, J.C. Vernhes, Lucile Borao, Emmanuel Futier, Jean-Michel Constantin, Marc Gainnier, Béatrice Cresta, Aurélie Larosa, Pierre Simeone, Didier Sanchez, Imane Inal, Marine Challier, Valentine Verdier, Bénédicte Deluca-Bosc, Jean‐Michel Constantin, Cyril Quémeneur, Sandrine Ndingamondze, Fanny Charbonnier, Souad Fellous, Christophe Quesnel, Anne Daguenel-Nguyen, Elie Azoulay, Igor Theodose, Michaël Darmon, Isabelle Madeleine, Julien Le Roy, Christophe Vinsonneau, Sabine Janowski, Maryline Houdre, Sarah Tollot, Catherine Senis, D. Descamps, Pierre-Marie Bertrand, Marine Agullo, Mehran Monchi, Arezki Agher, E Stoll, M. Camus, Bruno Mourvillier, Eric Marquis, Amandine Farget, Sandy Aerts, P Benoit, Catherine Bellot, Nathalie Kerneur, Valéry Bourbonneux, Laurent Pleven, Aude Davy, Amélie Le Gleut, Nathalie Mercier, Bénédicte Hue, M.-L. Hervé, Julien Maizel, Yoann Zerbib, Rayan Braik, Kahina Zid, Sophie Boddaert, Yves-Édouard Herpe, Maëva Campfort, Soizic Gergaud, Viviane Cassisa, Anne Sylvie Scholastique, Valérie Daniel, Pierre Bailly, Isabelle Ledu, Hélène Fortin-Prunier, Amandine Tapon, Axelle Cornillet, Patrícia Dias, Elsa Menanteau, Pascal Andreu, Audrey Massard, Solene Villot, Jean-Baptiste Roudaut, Nicolas Nowobilski, Vivien Berthoud, Hasni Si-Abdelkader, Samir Jaber, Gérald Chanques, Audrey De Jong, Boris Jung, Albert Prades, Fouad Belafia, Julie Carr, Moussa Cissé, Matthieu Conseil, J Delay, Julien Boudjemaa, Laurent Cachia, Jeanne Boyer, Antoine Roquilly, Karim Asehnoune, Clément Prouteau, Delphine Flattres Du Chaussoy, Camille Lebel, Amélie Trichot, Dominique Demeure Dit Latte, Yannick Hourmant, Pierre-Joachim Mahé, Laurent Flet, Carole Ichaï, Jean‐Christophe Orban, Christelle Boczek, Justine Bellegarde, Claire Roger, Laurent Müller, Jean‐Yves Lefrant, Sophie Lloret, Audrey Ambert, Mathieu Expert, Caroline Maury, Virginie Viviez, Elodie Jullian, Christian Maillard, Claire Dahyot‐Fizelier, Nadia Imzi, Christelle Plumereau, Sabrina Seguin, Isabelle Princet, J. P. Frat, R. Robert, Rémi Coudroy, Carole Guignon, Céline Delétage, Nacira Benhamouche, Delphine Chatellier, Damien Marié, Florence Boissier, Anne Veinstein, Philippe Séguin, Sophie Caradec, Éric Noll, Pierre Diemunsch, Thiên‐Nga Chamaraux‐Tran, Stéphane Hecketsweiler, Arnaud Romoli, Alain Meyer, Nadia Dhif, Magdalena Szczot, A Debaëne, Anne Hutt, S. A. Lang, Roland Amathieu, Thierry Lazard, Gabriel Lejour, Emmanuelle Guillot, Caroline Blazejewski, Sébastien Beague, Maud Vasse, Pauline Boddaert, M. Samson, Raphael Krouchi, Cyril Fayolle, Thomas Queruau, François Bezé, S. Tombelle, F. Danicourt, Basile Dectot, Carole Delattre, Valentin Vergriete, Fahima Zidat, Célia Komurkiewicz-Wellems, Virginie Paquez, Saad Nseir, Sylvie Brice, Claire Delcourte, Amélie Cerf, Laure Mariller, Thomas Costille, Thierry Gillart, Jean-Baptiste Joffredo, Audrey Johanny, Clémence Louis, Sébastien Perbet, Adrien Carla, Loris Giordanetto, Marc Bégard, Camille Boissy, Thibaud Cammas, Bernard Cosserant, Romain Grobost, Katia Levrier, Pierre-Antoine Pioche, Bertille Paquette, Gauthier Arpajou, Lucie Aupetitgendre, Sophie Cayot, Benoît Baietto, Laure-Anne Simand, Jean-Étienne Bazin, Nathalie Bourguignon, Sylvie Cosserant, Périne Vidal, G.A. Chauvet, Dominique Morand, Camille Theillière, Bertrand Souweine, Claire Dupuis, Mireille Adda-Pernot, Marine Bereiziat, Frédéric Duee, Alexandre Lautrette, Nathanaël Eisenmann, Ghislaine Niezgodzki, Rodolphe Hilaire, R. Chevrier, Sonia Rucart, Maud Jonas, Servane Vastral, Laurent Faivre, Elodie Bouvier, Charlotte Bourgoin, Isabelle Roussez, Pascale Dussert, Mohamed Ali Benbali, Hanane Fodil, Justine Lemtiri, Chaouki Bouras, Hedi Dhaouadi, Nabil El Beki, Stéphanie Violette, Aziz Berrouba, Gwladys M’Boungou, Romain Blanchon, Elodie Protesti, Pierre Kalfon, Bénédicte Mauchien, Martine Ferrandière, Charlène Piat
57Citations signalées — pas une note de qualité
40Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
Importance: Whether the use of inhaled or intravenous sedation affects outcomes differentially in mechanically ventilated adults with acute respiratory distress syndrome (ARDS) is unknown. Objective: To determine the efficacy and safety of inhaled sevoflurane compared with intravenous propofol for sedation in patients with ARDS. Design, Setting, and Participants: Phase 3 randomized, open-label, assessor-blinded clinical trial conducted from May 2020 to October 2023 with 90-day follow-up. Adults with early moderate to severe ARDS (defined by a ratio of Pao2 to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure of ≥8 cm H2O) were enrolled in 37 French intensive care units. Interventions: Patients were randomized to a strategy of inhaled sedation with sevoflurane (intervention group) or to a strategy of intravenous sedation with propofol (control group) for up to 7 days. Main Outcomes and Measures: The primary end point was the number of ventilator-free days at 28 days; the key secondary end point was 90-day survival. Results: Of 687 patients enrolled (mean [SD] age, 65 [12] years; 30% female), 346 were randomized to sevoflurane and 341 to propofol. The median total duration of sedation was 7 days (IQR, 4 to 7) in both groups. The number of ventilator-free days through day 28 was 0.0 days (IQR, 0.0 to 11.9) in the sevoflurane group and 0.0 days (IQR, 0.0 to 18.7) in the propofol group (median difference, -2.1 [95% CI, -3.6 to -0.7]; standardized hazard ratio, 0.76 [95% CI, 0.50 to 0.97]). The 90-day survival rates were 47.1% and 55.7% in the sevoflurane and propofol groups, respectively (hazard ratio, 1.31 [95% CI, 1.05 to 1.62]). Among 4 secondary outcomes, sevoflurane was associated with higher 7-day mortality (19.4% vs 13.5%, respectively; relative risk, 1.44 [95% CI, 1.02 to 2.03]) and fewer intensive care unit-free days through day 28 (median, 0.0 [IQR, 0.0 to 6.0] vs 0.0 [IQR, 0.0 to 15.0]; median difference, -2.5 [95% CI, -3.7 to -1.4]) compared with propofol. Conclusions and Relevance: Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. Trial Registration: ClinicalTrials.gov Identifier: NCT04235608.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Inhaled Sedation in Acute Respiratory Distress Syndrome
- Date Crossref
- 13/05/2025
- Éditeur
- American Medical Association (AMA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Respiratory Support and MechanismsIntensive Care Unit Cognitive DisordersAnesthesia and Sedative Agents