Noninvasive Monitoring of Humoral Immune Responses in Men With Acute Chlamydia trachomatis Urethral Infection Using First-Catch Urine

Le résumé fourni par la source

We investigated the relationship between Chlamydia trachomatis load and anti-chlamydial antibody using first-catch urine from 108 men with nongonococcal urethritis. Men who reported prior chlamydia had elevated anti-chlamydial IgA and lower loads, but load and antibody were not correlated. Load positively correlated with anti-chlamydial IgA only in men who did not self-report prior chlamydia and with anti-chlamydial IgG regardless of infection history. Overall, we document genotype-specific differences in C. trachomatis load, clarify that partial immunity associated with repeat infections is not antibody mediated, and demonstrate a method to monitor humoral immune responses to C. trachomatis in men using noninvasively collected urine.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.