Single-cell sequencing for lung cancer research: Progress and prospects

Le résumé fourni par la source

Lung cancer exhibits high morbidity and mortality rates, characterized by a heterogeneous genetic landscape and an immunosuppressive tumor microenvironment, despite recent therapeutic advances. High-resolution single-cell sequencing has facilitated a comprehensive analysis of malignant and host cell types, enhancing the understanding of lung cancer’s heterogeneity and adaptability under basal conditions and in response to therapeutic intervention. In this review, we provide an overview of the utilization of single-cell sequencing technology in characterizing the microenvironment of lung cancer, facilitating early diagnosis, monitoring tumor progression, and elucidating mechanisms of drug resistance, thereby offering new insights into potential therapeutic interventions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.