Validación de cuatro reglas de predicción clínica de la nefropatía inducida por contraste en pacientes llevados a intervención coronaria percutánea

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Background: Contrast-induced nephropathy (CIN) is the acute deterioration of kidney function after the administration of intravenous contrast media and is associated with significant morbidity and mortality. Several clinical risk scores to predict CIN are currently available. The aim of the present study is to validate four risk scores for predicting CIN in patients undergoing percutaneous coronary intervention (PCI). Methods: We conducted a retrospective single-center cohort study including adult patients undergoing PCI between January 2014 and December 2018. Patients on dialysis, those who died during the procedure or lack of necessary data for the analysis were excluded. The four risk scores were estimated for each patient and the area under the ROC curve for the development of CIN was calculated. Results: The four risk scores were calculated in 785 patients; 109 (13.8%) developed CIN and 14 (1.7%) required dialysis. Mean age was 65 years and 36.1% were women. Mean glomerular filtration rate was 69.1 mL/min. The areas under the curve for each risk score to predict CIN and dialysis were: Mehran 0.574 and 0.881, respectively; Gao, 0.487 and 0.831; Lin, 0.572 and 0.854; and Bartholomew, 0.506 and 0.754. Conclusions: The use of the Mehran, Gao, Lin, and Bartholomew risk scores in patients undergoing PCI showed poor discriminatory ability for CIN, although their performance was excellent for predicting the need for dialysis. How to cite this article: Sprockel JJ, Rivadeneira CS, Buitrago ND, Fuentes SA, Osorio NW. Validation of Four Clinical Risk Scores for Predicting Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention. Rev Argent Cardiol 2021;89:489-494. http://dx.doi.org/10.7775/rac.v89.i6.20454

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