Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients
Rattachement africain : us, se, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Idiopathic Multicentric Castleman Disease (iMCD) is a polyclonal lymphoproliferative disorder involving cytokine storms that can lead to organ failure and death. The cause of iMCD is unknown, but some clinical evidence suggests an autoimmune etiology. For example, connective tissue disorders (CTDs) and iMCD share many clinical features, and autoantibodies have been anecdotally reported in individual iMCD patients. This study investigates whether common autoantibodies are shared across iMCD patients. Methods: We assembled custom bead-based protein arrays consisting of 52 autoantigens traditionally associated with CTDs and 38 full-length cytokines and screened serum samples from 101 iMCD patients for IgG autoantibodies. We also screened samples with a 1,103-plex array of recombinant human protein fragments to identify additional autoantibody targets. Finally, we performed receptor blocking assays on select samples with anti-cytokine autoantibodies (ACAs) identified by array. Results: We found that an increased proportion of iMCD patients (47%) tested positive for at least one CTD-associated autoantibody compared to healthy controls (HC) (17%). Commonly detected CTD-associated autoantibodies were associated with myositis and overlap syndromes as well as systemic lupus erythematosus (SLE) and Sjögren's Syndrome (SS). ACAs were also detected in a greater proportion of iMCD patients (38%) compared to HC (10%), while the protein fragment array identified a variety of other autoantibody targets. One iMCD sample tested positive for receptor blocking against interferon-ω (IFNω). Discussion: IgG autoantibodies binding autoantigens associated with common CTDs and cytokines are elevated in iMCD patients compared to HC, suggesting that autoimmunity may be involved in iMCD pathogenesis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients
- Date Crossref
- 13/03/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Stanford University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania Center for Cytokine Storm Treatment & Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Science for Life Laboratory pays non établi dans la noticeStructure de recherche
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KTH Royal Institute of Technology pays non établi dans la noticeUniversité ou école supérieure
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University of Arkansas for Medical Sciences Myeloma Center pays non établi dans la noticeUniversité ou école supérieure
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Osaka Research Institute of Industrial Science and Technology pays non établi dans la noticeStructure de recherche
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Osaka University Department of Biomolecular Science and Regulation pays non établi dans la noticeUniversité ou école supérieure
Department of Medicine — Stanford University, Center for Cytokine Storm Treatment & Laboratory — University of Pennsylvania et Science for Life Laboratory, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.