Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
Rattachement africain : us, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into mechanisms promoting high physical function with aging, we performed proteomics, targeted metabolomics, and targeted kynurenine-focused metabolomic analyses on serum specimens from three groups of octogenarians: High-functioning master athletes (HF, n = 16), healthy normal-functioning non-athletes (NF, n = 12), and lower functioning non-athletes (LF, n = 11). Higher performance status was associated with evidence consistent with: Lower levels of circulating proinflammatory markers, as well as unperturbed tryptophan metabolism, with the normal function of the kynurenic pathway; higher circulating levels of lysophosphatidylcholines that have been previously associated with better mitochondrial oxidative capacity; lower activity of the integrated stress response; lower levels of circulating SASP protein members; and lower levels of proteins that reflect neurodegeneration/denervation. Extending the observations of previous studies focused on the biomarkers of aging that predict poor function, our findings show that many of the same biomarkers associated with poor function exhibit attenuated changes in those who maintain a high function. Because of the cross-sectional nature of this study, results should be interpreted with caution, and bidirectional causality, where physical activity behavior is both a cause and outcome of differences in the biomarker changes, remains a possible interpretation.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
- Date Crossref
- 10/03/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
National Institutes of Health Intramural Research Program pays non établi dans la noticeOrganisme public
-
Institute on Aging pays non établi dans la noticeOrganisation à but non lucratif
-
National Institute on Aging pays non établi dans la noticeStructure de recherche
-
Children's Hospital of Eastern Ontario pays non établi dans la noticeÉtablissement de santé
-
McGill University Health Centre pays non établi dans la noticeÉtablissement de santé
-
University of Florida pays non établi dans la noticeUniversité ou école supérieure
-
AdventHealth Orlando pays non établi dans la noticeÉtablissement de santé
-
Translational Research Institute for Metabolism and Diabetes pays non établi dans la noticeStructure de recherche
-
Translational Research Institute Advent Health Orlando Florida USA pays non établi dans la noticeStructure de recherche
Intramural Research Program — National Institutes of Health, Institute on Aging et National Institute on Aging, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.