Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index
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Le résumé fourni par la source
BACKGROUND: Both low/high pre-pregnancy body mass index (BMI) and increased bile acid levels during pregnancy (known as gestational hypercholanemia) were risk factors for adverse pregnancy outcomes, with limited information on their joint effects. METHODS: A total of 63,066 pregnant women were involved in a large retrospective cohort study from May 2014 to December 2018 in Shanghai, China. Data of pregnancy outcomes including hypercholanemia, hypertensive disorders in pregnancy (HDP), preterm delivery, and small for gestation age (SGA), were obtained for multivariable logistic analysis. RESULTS: < 0.001). Low pre-pregnancy BMI and hypercholanemia coexisting were related to a 2.71-fold risk (95% confidence intervals [CI], 2.10-3.50) of SGA. Whereas, overweight/obese (OWO) with hypercholanemia are associated with 5.34-fold risk (95% CI 3.93-7.25) of HDP when compared with normal weight women without hypercholanemia. Women with excessive gestational weight gain (GWG) and hypercholanemia had a higher risk of HDP (odds ratio [OR] 3.56, 95% CI 2.91-4.36), and macrosomia (OR 2.95, 95% CI 2.42-3.60), compared with non-hypercholanemia women with adequate GWG. Whereas, women with inadequate GWG and hypercholanemia had increased risks of preterm delivery (OR 1.87, 95% CI 1.44-2.43), and SGA (OR 2.32, 95% CI 1.82-2.96). CONCLUSIONS: Low maternal BMI before pregnancy was an independent risk factor for hypercholanemia. Additionally, pre-pregnancy underweight or OWO may amplify the effect of hypercholanemia on adverse pregnancy outcomes. Thus, pre-pregnancy BMI should be considered in the management of adverse perinatal outcomes related to gestational hypercholanemia.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index
- Date Crossref
- 03/03/2025
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shanghai Jiao Tong University pays non établi dans la noticeUniversité ou école supérieure
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International Peace Maternity & Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai Changning Maternity and Infant Health Hospital pays non établi dans la noticeÉtablissement de santé
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School of Medicine Department of Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Key Laboratory of Embryo Original Diseases pays non établi dans la noticeStructure de recherche
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Songjiang Maternity and Child Health Hospital Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
Shanghai Jiao Tong University, International Peace Maternity & Child Health Hospital et Shanghai Changning Maternity and Infant Health Hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.