A 3-Minute Ultrafast MRI and MRA Protocol for Screening of Acute Ischemic Stroke

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OBJECTIVE: To evaluate the diagnostic performance of a 3-min ultrafast brain MRI and MRA protocol for screening of acute ischemic stroke. METHODS: This study involved 67 adult patients who underwent ultrafast and reference MRI and MRA scans from September 2023 to June 2024 for stroke evaluation. Two readers independently assessed the ultrafast and reference MRI and MRA images in a masked and randomized manner for acute and chronic infarct and hemorrhage as well as large-vessel occlusion and severe stenosis. A 3-point Likert scale was used to evaluate diagnostic quality of the ultrafast sequences and Cohen's κ was used to assess interrater agreement. RESULTS: The ultrafast MRI and MRA protocol showed high diagnostic quality, with 98% of sequences rated as diagnostic. Raters showed perfect agreement in identifying acute infarcts, aneurysms, and vascular occlusions using both ultrafast and reference protocols and near-perfect agreement (>95%) for detecting acute hemorrhage and severe stenosis. For chronic conditions such as chronic infarction and chronic hemorrhage, there was substantial agreement with κ values ranging from 0.73 to 0.76. DISCUSSION: The screening ultrafast MRI and MRA protocol can effectively identify acute ischemic stroke and intracranial large-vessel occlusion with high diagnostic accuracy while significantly reducing acquisition time, making it suitable for initial stroke triage. Evaluation for chronic pathologies on the ultrafast protocol is inferior compared with standard MRI and MRA imaging.

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