Angiopoietin-2 and endothelial damage associated with viral load in untreated people living with HIV
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Le résumé fourni par la source
Background HIV infection is associated with various types of endothelial damage. Early and accurate diagnosis of endothelial dysfunction may help prevent adverse outcomes. For the first time, this cross-sectional study aims to investigate the effects of increased viral load on endothelial damage and nephrinuria in untreated people living with HIV. Methods People living with HIV not on treatment were included. Laboratory parameters, such as viral load and CD4 count were collected. Participants were divided into three groups according to the tertiles of viral load: low, moderate and high viral load groups. Urinary nephrin, vascular cell adhesion molecule 1 (VCAM-1), angiopoietin-2 and syndecan-1 were quantified by sandwich ELISA assays kits. Results A total of 49 patients were examined. The high viral load group (3rd tertile) exhibited a greater frequency of nephrinuria and significantly higher levels of syndecan-1 (58 [48–93] vs 43 [38–65] ng/mL, p = .049) and angiopoietin-2 (2.58 [1.5–3.06] vs 1.34 [0.89–1.76] ng/mL, p = .035). Syndecan-1 levels positively correlated with viral load (rho = 0.452, p = .006), while angiopoietin-2 was positively correlated with viral load (rho = 0.529, p = .001) and inversely correlated with CD4 count (rho = −0.493, p = .003). No significant associations were found for VCAM-1 levels. Conclusion Untreated people living with HIV with elevated viral loads exhibited more pronounced endothelial damage and vascular inflammation, emphasizing the critical importance of early initiation of antiretroviral treatment to mitigate these complications. However, the study’s findings should be interpreted with caution due to the small sample size, which may limit the generalizability of the results. Future studies with larger cohorts are needed to confirm these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Angiopoietin-2 and endothelial damage associated with viral load in untreated people living with HIV
- Date Crossref
- 28/02/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Federal do Ceará pays non établi dans la noticeUniversité ou école supérieure
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Universidade de Fortaleza pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmacy Post-Graduate Program in Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Fortaleza Public Health and Medical Sciences Graduate Programs pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Ceará Pharmacology Post-Graduate Program pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Universidade Federal do Ceará, Universidade de Fortaleza et Post-Graduate Program in Pharmaceutical Sciences — School of Pharmacy, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.