Metabolic memory in gestational diabetes enhances SARS-CoV-2 susceptibility in postpartum women: a prospective cohort study integrated with longitudinal metabolomics
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Le résumé fourni par la source
Graphical abstract (Created in BioRender; https://BioRender.com/o08n003). Abbreviations: GDM, gestational diabetes mellitus; NGT, normal glucose tolerance; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine. Abstract Objective Women with gestational diabetes mellitus (GDM) often develop a metabolic memory that increases the risk of future metabolic disorders, even after blood glucose levels normalize following clinical intervention. However, the impact of this metabolic memory on susceptibility to SARS-CoV-2 remains unclear. Therefore, we aim to investigate the potential association between metabolic memory in GDM and susceptibility to SARS-CoV-2 infection. Methods We conducted a prospective cohort study with 1,675 pregnant women, including 197 (11.8%) with GDM. Postpartum SARS-CoV-2 infections were tracked via telephone follow-up and categorized into negative and positive groups. Logistic regression was used to explore risk factors for SARS-CoV-2 infection. Peripheral blood samples were collected from 30 GDM and 30 normal glucose-tolerant (NGT) pregnant women in three trimesters (T1, T2 and T3) for longitudinal untargeted metabolomics to identify GDM and SARS-CoV-2-associated metabolites. Limma package was applied to find differential expressed metabolites associated with SARS-CoV-2 infection and GDM. Results Among 1,675 women, 1,348 (80.5%) tested positive for SARS-CoV-2. GDM postpartum women had higher SARS-CoV-2 infection rates (88.3 vs 79.4%, P = 0.003) than NGT women. GDM was associated with SARS-CoV-2 infection (T2: OR (95% CI): 2.17 (1.26–3.54), P = 0.005; T3: OR (95% CI): 1.70 (1.03–2.82), P = 0.040). Compared to the SARS-CoV-2 negative group, the positive group exhibited elevated levels of allantoic acid, LPE (0:0/22:6), LPC (15:0/0:0) and 1-linoleoyl-sn-glycero-3-phosphorylcholine in T1 and T2, before clinical intervention. In T3, allantoic acid remained elevated post-intervention. A similar increase as described above was observed in the GDM compared to the NGT group. The tricarboxylic acid cycle was the sole overlapping enriched pathway in the SARS-CoV-2 positive versus negative group and the GDM versus NGT group. Cis-aconitic acid, a metabolite from this pathway, was elevated in T3 in the GDM group. Conclusion Compared to NGT, women with GDM are at a higher risk of postnatal SARS-CoV-2 infection. Metabolic memory from GDM may heighten susceptibility to SARS-CoV-2.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Metabolic memory in gestational diabetes enhances SARS-CoV-2 susceptibility in postpartum women: a prospective cohort study integrated with longitudinal metabolomics
- Date Crossref
- 28/02/2025
- Éditeur
- Bioscientifica
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fudan University Department of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
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Obstetrics and Gynecology Hospital of Fudan University pays non établi dans la noticeÉtablissement de santé
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Sun Yat-sen University pays non établi dans la noticeUniversité ou école supérieure
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The Seventh Affiliated Hospital of Sun Yat-sen University pays non établi dans la noticeÉtablissement de santé
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Shenzhen University Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Zhangjiang Laboratory pays non établi dans la noticeStructure de recherche
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Guangdong Research Institute of Water Resources and Hydropower pays non établi dans la noticeOrganisation à but non lucratif
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Z Li pays non établi dans la noticeInstitution
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School of Public Health (Shenzhen) pays non établi dans la noticeUniversité ou école supérieure
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Q Lu pays non établi dans la noticeInstitution
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R Zhang pays non établi dans la noticeInstitution
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the Second People’s Hospital of Kashgar Prefecture 4 Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
Department of Endocrinology — Fudan University, Obstetrics and Gynecology Hospital of Fudan University et Sun Yat-sen University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.