Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
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Le résumé fourni par la source
A congenital solitary functioning kidney (C-SFK) or an early acquired SFK (EA-SFK), due to childhood unilateral nephrectomy (UNX), increases the risk of hypertension and kidney disease early in life. Evidence suggests that children with an EA-SFK may have a higher risk of future kidney disease compared with those with a C-SFK, but the precise underlying mechanisms need further investigation. C-SFK was induced by fetal UNX at 100 days gestation (term=150 days) in male sheep fetuses, and a sham procedure was performed. At approximately one month of age, EA-SFK was induced by UNX in male lambs. At eight months of age, total kidney weight was similar in all groups due to marked hypertrophy in the C-SFK and EA-SFK groups. Blood pressure was similar in EA-SFK and sham groups but ~12 mmHg higher in the C-SFK group compared with sham. Compared with the sham group, glomerular filtration rate (GFR) was ~9% less in the EA-SFK group and ~26% less in the C-SFK. GFR was ~23% higher in EA-SFK compared with the C-SFK group. Albuminuria was ~67% higher in C-SFK sheep but similar in the EA-SFK group compared with sham sheep. However, like the C-SFK group, the renal blood flow response to nitric oxide blockade was attenuated in the EA-SFK group compared with sham. In conclusion, long-term studies are needed to determine whether the higher hyperfiltration and disturbed vasodilator balance observed in EA-SFK sheep will cause an accelerated decline in renal function with aging.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
- Date Crossref
- 01/03/2025
- Éditeur
- Portland Press Ltd.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Discovery Institute pays non établi dans la noticeOrganisation à but non lucratif
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Australian Regenerative Medicine Institute pays non établi dans la noticeStructure de recherche
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Monash University Monash Biomedicine Discovery Institute and Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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The University of Queensland pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center Amalia Children's Hospital pays non établi dans la noticeOrganisme public
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Amalia Kinderziekenhuis pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Centre Amalia Children’s Hospital pays non établi dans la noticeUniversité ou école supérieure
Discovery Institute, Australian Regenerative Medicine Institute et Monash Biomedicine Discovery Institute and Department of Physiology — Monash University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.