Author response: Linalool’s Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica
Rattachement africain : cn, cz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Saprolegnia parasitica (S. parasitica) is one of the most virulent oomycete species in freshwater aquatic environments, causing severe saprolegniasis and leading to significant economic losses in the aquaculture industry. Thus far, the prevention and control of saprolegniasis face a shortage of medications. Linalool, a natural antibiotic alternative found in various essential oils, exhibits promising antimicrobial activity against a wide range of pathogens. In this study, the specific role of linalool in protecting S. parasitica infection at both in vitro and in vivo levels was investigated. Linalool showed multifaceted anti-oomycetes potential by both of antimicrobial efficacy and immunomodulatory efficacy. For in vitro test, linalool exhibited strong anti-oomycetes activity and mode of action included: (1) Linalool disrupted the cell membrane of the mycelium, causing the intracellular components leak out; (2) Linalool prohibited ribosome function, thereby inhibiting protein synthesis and ultimately affecting mycelium growth. Surprisingly, meanwhile we found the potential immune protective mechanism of linalool in the in vivo test: (1) Linalool enhanced the complement and coagulation system which in turn activated host immune defense and lysate S. parasitica cells; (2) Linalool promoted wound healing, tissue repair, and phagocytosis to cope with S. parasitica infection; (3) Linalool positively modulated the immune response by increasing the abundance of beneficial Actinobacteriota; (4) Linalool stimulated the production of inflammatory cytokines and chemokines to lyse S. parasitica cells. In all, our findings showed that linalool possessed multifaceted anti-oomycetes potential which would be a promising natural antibiotic alternative to cope with S. parasitica infection in the aquaculture industry.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Author response: Linalool’s Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica
- Date Crossref
- 26/02/2025
- Éditeur
- eLife Sciences Publications, Ltd
- Type
- peer-review
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hunan Agricultural University pays non établi dans la noticeUniversité ou école supérieure
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Chinese Academy of Sciences pays non établi dans la noticeOrganisme public
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Institute of Hydrobiology pays non établi dans la noticeStructure de recherche
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Hunan Academy of Agricultural Sciences pays non établi dans la noticeUniversité ou école supérieure
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Fisheries College Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization pays non établi dans la noticeUniversité ou école supérieure
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State Key Laboratory of Freshwater Ecology and Biotechnology pays non établi dans la noticeStructure de recherche
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Hunan Agriculture Product Processing Institute pays non établi dans la noticeStructure de recherche
Hunan Agricultural University, Chinese Academy of Sciences et Institute of Hydrobiology, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.