Evaluation of microstates and functional connectivity after transcranial direct current stimulation in post-covid syndrome

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healthy aged subjects (67.8±6.5 y.o., 29 males) were enrolled.The Montreal cognitive assessment (MoCA) was used to assess cognitive skills.Motor-evoked potentials (MEP) were recorded at baseline and after 0, 10, 20 and 30 minutes from PAS delivery.MEP amplitude ratio between each time point and baseline was used to calculate the area under the curve (AUC), grand average (GrA) and curve concavity (CC), which were used as PAS indexes.MoCA significantly correlated with CC (p¼0.013), but not with AUC (p¼0.111) and GrA (p¼0.091).Only when CC was used to discriminate PAS responsivity, MoCA was significantly higher (p¼0.014) in RR (27.2±2.3)than NR (25.7±2.1).In conclusion, CC may represent a potential PAS index to describe cortical plasticity and cognitive skills in humans, with a possible practical application in patients with cognitive impairment, namely Alzheimer Disease.Funded by Unione europea e Next Generation EU e PNRR M6C2 -Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN, PNRR-MAD-2022-12376667, CUP H83C22000720006.

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