Resting-state brain functional correlates following convulsive therapies in patients with treatment-resistant depression: preliminary findings

Le résumé fourni par la source

Preoperative neuroimaging data were used to define anatomical regions of interest (ROIs), including the NBM and its lateral tract.A neurosurgeon planned multiple trajectories for lead placement based on these ROIs in Brainlab Elements neuronavigational software.Based on the proposed trajectory, the investigational Boston Scientific software Illumina was used to model the optimal stimulation configuration for maximizing overlap between the stimulation field model (SFM) and the target.We implemented this pipeline in an individual with PD who previously underwent DBS of the subthalamic nucleus.The neurosurgeon mapped multiple trajectories for the NBM and its lateral tract.Different trajectories were used depending on the target of interest, which resulted in different stimulation configurations and ensuing SFMs.The added constraint of additional avoidance regions resulted in smaller stimulation amplitudes and SFMs.Subsection analysis of ROIs allowed more detailed comparisons of SFMs to compare overlap in the X, Y, and Z directions.The proposed pipeline allows for anatomy-guided placement of DBS leads and subsequent automation of initial stimulation configurations.This could facilitate clinical programming for new indications, such as DBS for cognition, where acute stimulation-induced behavioral effects cannot be used to guide programming.The feasibility of this approach will be assessed in an upcoming pilot clinical trial of NBM DBS in PD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.