Lung Transplantation With Elevated Pulmonary Vascular Resistance: Insights From the United Network for Organ Sharing Database
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Le résumé fourni par la source
Background: Pulmonary hypertension is a significant challenge in patients requiring a lung transplant, often being manifested with severe complications such as high pulmonary vascular resistance (PVR). Although medical treatments have extended median survival, pulmonary hypertension remains a progressive and life-threatening condition. Lung transplantation offers potential for improved outcomes, supported by advancements in surgical techniques, donor lung preservation, immunosuppression, and posttransplantation care. Methods: Using the United Network for Organ Sharing database, we analyzed adult patients undergoing double lung transplantation from October 1, 2002, to September 30, 2022. Our focus was on patients with elevated PVR (≥6 Wood units), with or without underlying lung parenchymal disease. Trends in transplantation, survival rates, and impact of center volume on outcomes were examined. Results: Of 24,921 double lung transplant recipients, 2755 patients had PVR ≥6 Wood units. There was a significant upward trend in annual procedures, with increased use of extracorporeal support during surgery. Higher volume centers (performing >33 transplants annually) demonstrated better survival rates. Elevated PVR was independently associated with higher mortality, highlighting its importance in patient selection and management. Conclusions: Lung transplantation remains a critical option for patients with end-stage lung disease, including those with high PVR. Improved outcomes at high-volume centers underscore the importance of institutional experience and expertise.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Lung Transplantation With Elevated Pulmonary Vascular Resistance: Insights From the United Network for Organ Sharing Database
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Wright Center for Graduate Medical Education pays non établi dans la noticeÉtablissement de santé
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Henry Ford Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Saint Louis University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Minnesota Division of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Michigan State University Department of Osteopathic Medical Specialties pays non établi dans la noticeUniversité ou école supérieure
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University of Michigan Department of Cardiothoracic Surgery pays non établi dans la noticeUniversité ou école supérieure
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MetroHealth Medical Center pays non établi dans la noticeÉtablissement de santé
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Case Western Reserve University Division of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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St Louis University Hospital Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
The Wright Center for Graduate Medical Education, Department of Internal Medicine — Henry Ford Hospital et Saint Louis University Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.