ent‐Atisane Diterpenoids with Anti‐Influenza Virus Activity from Mangrove Plant Excoecaria agallocha L.

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ABSTRACT Three new ent‐atisane diterpenoids, named agallolides N‒P (1–3) together with nine known diterpenoids (4–12) were isolated from the stems and twigs of the mangrove plant, Excoecaria agallocha L. . Various techniques, including high‐resolution electrospray ionization mass spectrometry, spectroscopic methods, 13C‐NMR calculations, DP4+ probability analysis, and equivalent circulating density calculations were applied to determine their molecular structures. The anti‐influenza virus activities of 1–12 against A/PR/8/34 (H1N1), ZX1109 (H1N1, oseltamivir‐resistant virus), HK68 (H3N2), and B/Florida/78/2015 were evaluated. Compounds 8 and 12 showed significant antiviral activities against those four virus strains with EC50 values ranging from 0.54 to 19.53 µM. Moreover, compound 8 exhibited notable antiviral activity against A/PR/8/34, ZX1109, and B/Florida/78/2015 with EC50 values of 2.82, 3.45, and 0.54 µM, respectively, which were more potent than the positive control oseltamivir. These findings suggest that compound 8 may be a potential structure basis for developing anti‐influenza agents.

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