3D joint T 1 /T 1 ρ /T 2 mapping and water‐fat imaging for contrast‐agent free myocardial tissue characterization at 1.5T

Résumé fourni par la source

Abstract Purpose To develop a novel, free‐breathing, 3D joint // mapping sequence with Dixon encoding to provide co‐registered 3D , , and maps and water‐fat volumes with isotropic spatial resolution in a single min scan for comprehensive contrast‐agent‐free myocardial tissue characterization and simultaneous evaluation of the whole‐heart anatomy. Methods An interleaving sequence over 5 heartbeats is proposed to provide , , and encoding, with 3D data acquired with Dixon gradient‐echo readout and 2D image navigators to enable respiratory scan efficiency. Images were reconstructed with a non‐rigid motion‐corrected, low‐rank patch‐based reconstruction, and maps were generated through dictionary matching. The proposed sequence was compared against conventional 2D techniques in phantoms, 10 healthy subjects, and 1 patient. Results The proposed 3D , , and measurements showed excellent correlation with 2D reference measurements in phantoms. For healthy subjects, the mapping values of septal myocardial tissue were , , and for the proposed sequence, against , , and for 2D MOLLI, 2D ‐prep bSSFP and 2D ‐prep bSSFP, respectively. Promising results were obtained when comparing the proposed mapping to 2D references in 1 patient with active myocarditis. Conclusion The proposed approach enables simultaneous 3D whole‐heart joint // mapping and water/fat imaging in 7 min scan time, demonstrating good agreement with conventional mapping techniques in phantoms and healthy subjects and promising results in 1 patient with suspected cardiovascular disease.

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